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The involvement of nucleotide excision repair proteins in the removal of oxidative DNA damage
- Source :
- Nucleic Acids Research
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- The six major mammalian DNA repair pathways were discovered as independent processes, each dedicated to remove specific types of lesions, but the past two decades have brought into focus the significant interplay between these pathways. In particular, several studies have demonstrated that certain proteins of the nucleotide excision repair (NER) and base excision repair (BER) pathways work in a cooperative manner in the removal of oxidative lesions. This review focuses on recent data showing how the NER proteins, XPA, XPC, XPG, CSA, CSB and UV-DDB, work to stimulate known glycosylases involved in the removal of certain forms of base damage resulting from oxidative processes, and also discusses how some oxidative lesions are probably directly repaired through NER. Finally, since many glycosylases are inhibited from working on damage in the context of chromatin, we detail how we believe UV-DDB may be the first responder in altering the structure of damage containing-nucleosomes, allowing access to BER enzymes.
- Subjects :
- Guanine
DNA Repair
AcademicSubjects/SCI00010
DNA damage
DNA repair
Context (language use)
Biology
03 medical and health sciences
chemistry.chemical_compound
Genetics
Humans
Survey and Summary
030304 developmental biology
Xeroderma Pigmentosum
0303 health sciences
030302 biochemistry & molecular biology
Base excision repair
Chromatin
Cell biology
DNA-Binding Proteins
Oxidative Stress
chemistry
DNA glycosylase
5-Methylcytosine
Oxidation-Reduction
Thymine
DNA
DNA Damage
Nucleotide excision repair
Subjects
Details
- ISSN :
- 13624962 and 03051048
- Volume :
- 48
- Database :
- OpenAIRE
- Journal :
- Nucleic Acids Research
- Accession number :
- edsair.doi.dedup.....58d8134cd86adba4e01cd7af779caf2b