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Role of lamins in 3D genome organization and global gene expression
- Source :
- Nucleus, Vol 10, Iss 1, Pp 33-41 (2019), Nucleus
- Publication Year :
- 2019
- Publisher :
- Taylor & Francis Group, 2019.
-
Abstract
- Genome-wide mapping of lamin-B1-genome interactions has shown that gene-poor and transcriptionally inactive genomic regions are associated with the nuclear lamina. Numerous studies have suggested that lamins, the major structural components of the nuclear lamina, play a role in global chromatin organization and gene expression. How lamins could influence the 3D genome organization and transcription from the nuclear periphery has, however, remained unclear. Our recent studies showed that lamins differentially regulate distinct lamina-associated chromatin domains (LADs) at the nuclear periphery, which can in turn influence global 3D genome organization and gene expression. In this Extra View, we discuss how by using various genomics tools, it has become possible to reveal the functions of lamins in orchestrating 3D genome organization and gene expression. Abbreviations: 3D: three dimensional; LAD: lamina-associated chromatin domain; 3C: Chromosome Conformation Capture; TAD: topologically associated domain; HiLands: Histone and lamina landscape; NL: nuclear lamina; mESC: mouse embryonic stem cell; DamID: DNA adenine methyltransferase identification
- Subjects :
- lcsh:QH426-470
Genomics
lads
tads
Chromosome conformation capture
03 medical and health sciences
Gene expression
Animals
Humans
lamin
lcsh:QH573-671
030304 developmental biology
Genomic organization
Cell Nucleus
0303 health sciences
Genome
hi-c
biology
lcsh:Cytology
Extra View
3d genome
030302 biochemistry & molecular biology
Cell Biology
Lamins
Chromatin
Cell biology
lcsh:Genetics
Histone
Gene Expression Regulation
biology.protein
Nuclear lamina
hilands
Lamin
nuclear lamina
Subjects
Details
- Language :
- English
- ISSN :
- 19491042 and 19491034
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nucleus
- Accession number :
- edsair.doi.dedup.....58c93666131ccbb158b94645d95b39b8