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Mitigation of ER-stress and inflammation by chemokine (C-C motif) ligand 21 during early pregnancy
- Source :
- Developmental & Comparative Immunology. 94:73-84
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- The immune system plays an important role in pregnancy. Chemokines recruit leukocytes at the maternal-fetal interface during early pregnancy. However, the role of the chemokine, C-C motif chemokine ligand 21 (CCL21), is less known. The aim of this study was to identify the expression of CCL21 and its receptor, CCR7, in the endometrium during estrous cycle and early pregnancy, and to investigate the functional effects of CCL21 on porcine trophectoderm (pTr) and porcine uterine luminal epithelial (pLE) cells. Our results indicated that CCL21 and CCR7 are increased in the glandular (GE) and luminal epithelium (LE) of the endometrium during early pregnancy, compared to estrous pigs. Recombinant CCL21 improved pTr and pLE cell proliferation through activation of the PI3K and MAPK pathways and suppression of tunicamycin-induced endoplasmic reticulum (ER) stress or LPS-induced inflammation. Collectively, these results provide novel insights into CCL21-mediated signaling mechanisms at the maternal-fetal interface during early pregnancy.
- Subjects :
- Lipopolysaccharides
0301 basic medicine
Receptors, CCR7
endocrine system
Chemokine
Swine
Immunology
Estrous Cycle
C-C chemokine receptor type 7
Inflammation
Biology
Endometrium
Phosphatidylinositol 3-Kinases
03 medical and health sciences
0302 clinical medicine
Pregnancy
medicine
Animals
Receptor
Cells, Cultured
Cell Proliferation
Chemokine CCL21
Tunicamycin
Endoplasmic reticulum
Epithelial Cells
Endoplasmic Reticulum Stress
Cell biology
030104 developmental biology
medicine.anatomical_structure
030220 oncology & carcinogenesis
Unfolded protein response
biology.protein
Female
Mitogen-Activated Protein Kinases
medicine.symptom
Signal Transduction
Developmental Biology
CCL21
Subjects
Details
- ISSN :
- 0145305X
- Volume :
- 94
- Database :
- OpenAIRE
- Journal :
- Developmental & Comparative Immunology
- Accession number :
- edsair.doi.dedup.....58b9bfc0e6968115871b6b9c84aa921c