Supplementary Figures 1 - 6 from Tumor MMP-1 Activates Endothelial PAR1 to Facilitate Vascular Intravasation and Metastatic Dissemination

PDF file - 199K, Effects of MMP-1 silencing on HEp3-hi/diss cell proliferation in 2D and 3D culture conditions (S1); HEp3-hi/diss tissue colonization does not depend on MMP-1 expression (S2); Effects of MMP-1 downregulation on HEp3-hi/diss cell adhesion and invasion (S3); Inhibition of vascular permeability in HEp3-hi/diss microtumors by the PAR1 antagonist RWJ 56110 (S4); Inhibition of HEp3-hi/diss intravasation by a PAR1 antagonist (S5); MMP-1 produced by the human HNSCC Detroit 562 concomitantly regulates vascular permeability and intravasation (S6).