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Lung Disease, Oxidative Stress, and Oxygen Requirements in Preterm Infants
- Source :
- Biological Research For Nursing. 18:322-330
- Publication Year :
- 2015
- Publisher :
- SAGE Publications, 2015.
-
Abstract
- Background: The role of oxidative stress remains unclear in the multifactorial pathophysiologic mechanism of lung disease in preterm infants. Aims: The aim of this study was to examine the associations among chronic lung disease (CLD), oxidative stress, and oxygen requirements in preterm infants. Design: Prospective, longitudinal, and correlational design. Subjects: Preterm infants born at Measurements: The diagnosis of CLD was obtained from the medical record. Oxidative stress was measured using 8-hydroxydeoxyguanosine (8-OHdG) in the cord blood at birth and urine on Days 1 and 7. Oxygen requirements were measured using fraction of inspired oxygen (FIO2) recorded in the first hour after birth/admission and the average FIO2 during the first 12 hr and 7 days after birth. Descriptive statistics are presented. Comparison analyses were performed using Kruskal–Wallis and Fisher’s exact tests. Results: Infants with CLD ( n = 12) had lower gestational age ( p = .04) and weight ( p = .04) at birth, more days on the ventilator ( p = .004), and longer neonatal intensive care unit stay ( p = .04) compared to infants without CLD ( n = 19). CLD was associated with lower oxidative stress levels ( p = .03) and higher oxygen requirements during the first 12 hr ( p = .025) and on Day 7 ( p = .001). Lower oxidative stress levels on Day 7 were associated with higher oxygen requirements in the first 12 hr ( p = .01) and on Day 7 ( p = .03). Conclusion: Our results linking CLD and higher oxygen requirements with low oxidative stress contradict previous reports. Findings identify a gap in knowledge for postresuscitation oxygen therapy in preterm infants and expose the role of oxidative stress from inflammation and intermittent hypoxia in the etiology of CLD.
- Subjects :
- Lung Diseases
Male
medicine.medical_specialty
Pediatrics
chemistry.chemical_element
Infant, Premature, Diseases
Urine
medicine.disease_cause
Oxygen
Gastroenterology
03 medical and health sciences
0302 clinical medicine
Intensive Care Units, Neonatal
030225 pediatrics
Fraction of inspired oxygen
Internal medicine
Administration, Inhalation
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Child
Prospective cohort study
Research and Theory
business.industry
Infant, Newborn
Oxygen Inhalation Therapy
Deoxyguanosine
Infant
Articles
Pathophysiology
Oxidative Stress
chemistry
8-Hydroxy-2'-Deoxyguanosine
Cord blood
Gestation
Female
business
Infant, Premature
Oxidative stress
Subjects
Details
- ISSN :
- 15524175 and 10998004
- Volume :
- 18
- Database :
- OpenAIRE
- Journal :
- Biological Research For Nursing
- Accession number :
- edsair.doi.dedup.....589fb95026fdefa2e4245afb1d438f19