Back to Search
Start Over
Clinicopathologic Features of Hydroa Vacciniforme–Like Lymphoma
- Source :
- The American Journal of Dermatopathology. 38:20-25
- Publication Year :
- 2016
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2016.
-
Abstract
- Hydroa vacciniforme-like lymphoma is a recently recognized cutaneous T-cell lymphoma associated with Epstein-Barr virus. The disease is observed in children of Latin American or Asian ethnicity. The authors report the clinical, histopathological, and immunophenotypical features of 9 new Mexican patients (M:F = 2:1; mean age, 14.5 years; median age, 13.3 years; age range, 4-27 years), expanding on previous observations of this elusive disease. The most common clinical aspects were persistent facial edema with necroses and pitted scars. Histopathological analyses revealed variably dense lymphoid infiltrates with common angiodestructive features. Neoplastic cells expressed CD3 and cytotoxic markers in all cases and were constantly positive for Epstein-Barr virus (EBER-1). Expression of other markers was variable. Follow-up data revealed that all patients died within 6 months or less, thus showing a very aggressive course with poor prognosis.
- Subjects :
- Adult
Male
Epstein-Barr Virus Infections
Pathology
medicine.medical_specialty
Adolescent
CD3 Complex
Scars
Dermatology
Disease
Virus
Pathology and Forensic Medicine
Cicatrix
Necrosis
Young Adult
030207 dermatology & venereal diseases
03 medical and health sciences
0302 clinical medicine
hemic and lymphatic diseases
medicine
Edema
Humans
Young adult
Child
Mexico
Epstein–Barr virus infection
Facial neoplasm
business.industry
Torso
Extremities
General Medicine
Prognosis
medicine.disease
Immunohistochemistry
Lymphoma, T-Cell, Cutaneous
Lymphoma
Child, Preschool
Face
030220 oncology & carcinogenesis
Hydroa Vacciniforme
Hydroa vacciniforme
Female
Facial Neoplasms
medicine.symptom
business
Subjects
Details
- ISSN :
- 01931091
- Volume :
- 38
- Database :
- OpenAIRE
- Journal :
- The American Journal of Dermatopathology
- Accession number :
- edsair.doi.dedup.....589c610ce6a611706dc05845f336ae38