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Claudins in viral infection: from entry to spread
- Source :
- Pflügers Archiv European Journal of Physiology, Pflügers Archiv European Journal of Physiology, Springer Verlag, 2017, 469 (1), pp.27-34. ⟨10.1007/s00424-016-1908-4⟩, Pflügers Archiv-European Journal of Physiology, Pflügers Archiv European Journal of Physiology, 2017, 469 (1), pp.27-34. ⟨10.1007/s00424-016-1908-4⟩
- Publication Year :
- 2016
- Publisher :
- Springer Science and Business Media LLC, 2016.
-
Abstract
- Tight junctions are critically important for many physiological functions, including the maintenance of cell polarity, regulation of paracellular permeability, and involvement in signal transduction pathways to regulate integral cellular processes. Furthermore, tight junctions enable epithelial cells to form physical barriers, which act as an innate immune mechanism that can impede viral infection. Viruses, in turn, have evolved mechanisms to exploit tight junction proteins to gain access to cells or spread through tissues in an infected host. Claudin family proteins are integral components of tight junctions and are thought to play crucial roles in regulating their permeability. Claudins have been implicated in the infection process of several medically important human pathogens, including hepatitis C virus, dengue virus, West Nile virus, and human immunodeficiency virus, among others. In this review, we summarize the role of claudins in viral infections and discuss their potential as novel antiviral targets. A better understanding of claudins during viral infection may provide insight into physiological roles of claudins and uncover novel therapeutic antiviral strategies.
- Subjects :
- 0301 basic medicine
Physiology
viruses
Viral pathogenesis
Clinical Biochemistry
Sciences du Vivant [q-bio]/Médecine humaine et pathologie
Dengue virus
Biology
medicine.disease_cause
Antiviral Agents
Article
Tight Junctions
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Cell polarity
medicine
Animals
Humans
Claudin
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology
Tight Junction Proteins
Innate immune system
Tight junction
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
Virology
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
3. Good health
Cell biology
030104 developmental biology
Virus Diseases
Paracellular transport
Claudins
Signal transduction
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 14322013 and 00316768
- Volume :
- 469
- Database :
- OpenAIRE
- Journal :
- Pflügers Archiv - European Journal of Physiology
- Accession number :
- edsair.doi.dedup.....5891c701a0618ea8e3a296f49edce4a0