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Effect of obesity on gastrointestinal transit, pressure and pH using a wireless motility capsule
- Source :
- European Journal of Pharmaceutics and Biopharmaceutics. 167:1-8
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Despite the increasing prevalence and medical burden of obesity, the understanding of gastrointestinal physiology in obesity is scarce, which hampers drug development.To investigate the effect of obesity and food intake on gastrointestinal transit, pressure and pH.An exploratory cross-sectional study using a wireless motility capsule (SmartPill©) was performed in 11 participants with obesity and 11 age- and gender-matched participants with normal weight (group) in fasted and fed state (visit). During the first visit, the capsule was ingested after an overnight fast. During a second visit, the capsule was ingested after a nutritional drink to simulate fed state. Linear mixed models were constructed to compare segmental gastrointestinal transit, pressure and pH between groups (obesity or control) and within every group (fasted or fed).Food intake slowed gastric emptying in both groups (both P 0.0001), though food-induced gastric contractility was higher in participants with obesity compared to controls (P = 0.02). In the small intestine, a higher contractility (P = 0.001), shorter transit (P = 0.04) and lower median pH (P = 0.002) was observed in participants with obesity compared to controls. No differences were observed for colonic measurements.Obesity has a profound impact on gastrointestinal physiology, which should be taken into account for drug development.
- Subjects :
- Adult
Male
Adolescent
Pharmaceutical Science
Physiology
Capsules
Wireless motility capsule
Eating
Young Adult
Humans
Medicine
Obesity
Gastrointestinal Transit
Gastric emptying
business.industry
Gastrointestinal Physiology
Gastrointestinal transit
digestive, oral, and skin physiology
Capsule
General Medicine
Hydrogen-Ion Concentration
Middle Aged
medicine.disease
Cross-Sectional Studies
Gastric Emptying
Normal weight
Female
Gastrointestinal Motility
business
Biotechnology
Federal state
Subjects
Details
- ISSN :
- 09396411
- Volume :
- 167
- Database :
- OpenAIRE
- Journal :
- European Journal of Pharmaceutics and Biopharmaceutics
- Accession number :
- edsair.doi.dedup.....588664e2a7016543b03e778c1a422a96