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Significance of IL-6 Deficiency in Recognition Memory in Young Adult and Aged Mice
- Source :
- Behavior Genetics
- Publication Year :
- 2019
- Publisher :
- Springer Science and Business Media LLC, 2019.
-
Abstract
- Chronic peripheral elevation of interleukin 6 (IL-6) in humans is associated with cognitive deficits. 4- and 24-month-old IL-6-deficient C57BL/6J (IL-6KO) and reference wild-type (WT) mice were tested in an object recognition test. Discrimination ratios and recognition indexes were significantly lower in 4-month-old IL-6KO and in 24-month-old WT mice vs 4-month-old WT animals. Their discrimination ratios had negative values and recognition indexes were below 50% indicating inability to differentiate the novel from the familiar object after 1-hour delay. In 24-month-old IL-6KO mice recognition index reached 53.17% indicating that their recognition memory was not worsened with age in comparison with younger IL-6-deficient animals. Results of holeboard and elevated plus maze indicated that this effect was memory specific. Inborn IL-6 deficiency attenuated recognition memory in 4-month-old mice and did not altered recognition memory in aged animals. IL-6 signalling may constitute a target for development of the protection against memory disturbances connected with IL-6 overexpression. Electronic supplementary material The online version of this article (10.1007/s10519-019-09959-6) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Elevated plus maze
Motor Activity
Mice
03 medical and health sciences
0302 clinical medicine
Memory
Internal medicine
Genetics
medicine
Animals
IL-6 deficiency
Young adult
Maze Learning
Interleukin 6
Genetics (clinical)
Ecology, Evolution, Behavior and Systematics
Original Research
Recognition memory
Behavior, Animal
biology
Interleukin-6
business.industry
Age Factors
Cognition
Peripheral
Mice, Inbred C57BL
030104 developmental biology
Endocrinology
Holeboard
biology.protein
Object recognition memory
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 15733297 and 00018244
- Volume :
- 49
- Database :
- OpenAIRE
- Journal :
- Behavior Genetics
- Accession number :
- edsair.doi.dedup.....588028ec04e8aa836d898a3832afc076