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Gold-installed biostable nanocomplexes for tumor-targeted siRNA delivery in vivo
- Source :
- Chemical Communications. 51:16656-16659
- Publication Year :
- 2015
- Publisher :
- Royal Society of Chemistry (RSC), 2015.
-
Abstract
- The key issues, associated with nanocarriers for small interfering RNAs (siRNAs), are their poor stability and lack of tumor targetability in vivo. To address these issues, we developed gold-installed polyethyleneimine/siRNA complexes with a corona of PEGylated hyaluronic acid.
- Subjects :
- Small interfering RNA
Metal Nanoparticles
Protein Corona
Key issues
Catalysis
Polyethylene Glycols
Tumor targeted
Mice
chemistry.chemical_compound
Drug Delivery Systems
In vivo
Cell Line, Tumor
Hyaluronic acid
Materials Chemistry
Animals
Polyethyleneimine
Tissue Distribution
Hyaluronic Acid
RNA, Small Interfering
Drug Carriers
Metals and Alloys
Neoplasms, Experimental
General Chemistry
Molecular biology
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry
NIH 3T3 Cells
Ceramics and Composites
Cancer research
Gold
Nanocarriers
Drug carrier
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 51
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....58724d472ca0385299ed728aeaadd8c3