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SPARC gene variants predict clinical outcome in locally advanced and metastatic pancreatic cancer patients
- Source :
- MEDICAL ONCOLOGY, r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau, instname
- Publication Year :
- 2017
-
Abstract
- Secreted protein acidic and rich in cysteine (SPARC) is a glycoprotein of the extracellular matrix whose expression can be altered in malignant pancreatic cells and in the adjacent stromal fibroblasts. We evaluated the possible role of SPARC gene variants as prognostic markers for locally advanced and metastatic pancreatic cancer. We analyzed eight tagging single-nucleotide polymorphisms (TagSNPs) in the SPARC gene in 74 patients with pancreatic ductal adenocarcinoma treated with chemotherapy alone or combined with radiotherapy. TagSNPs were chosen using the HapMap genome browser and Haploview software 4.2 based on two predefined criteria: (1) coefficient cutoff of 0.80 and (2) minor allele frequency (MAF) >= 0.10. Univariate analyses revealed significant associations between four SNPs (rs17718347, rs2347128, rs3210714, and rs967527) and PFS. The rs3210714 genetic variant was also associated with OS. In the multivariate analyses, rs17718347 (HR 0.4; 95% CI 0.2-0.8; p = 0.013) and rs2347128 (HR 0.5; 95% CI 0.3-0.9; p = 0.049) remained statistically associated with PFS. In addition, patients harboring the T-A-G haplotype (rs17718347, rs1978707, rs2347128) had a better PFS (p = 0.002). Our findings suggest that SPARC polymorphisms may be useful in predicting outcome in patients with locally advanced and metastatic pancreatic cancer.
- Subjects :
- 0301 basic medicine
Oncology
Male
Cancer Research
medicine.medical_specialty
Haploview
Single-nucleotide polymorphism
Biology
Nab-paclitaxel
Adenocarcinoma
Bioinformatics
Polymorphism, Single Nucleotide
03 medical and health sciences
0302 clinical medicine
Gene Frequency
Pancreatic cancer
Internal medicine
medicine
Humans
Computer Simulation
Osteonectin
Aged
Univariate analysis
Hematology
Haplotype
SPARC
General Medicine
Biomarker
medicine.disease
Prognosis
Survival Analysis
Minor allele frequency
Pancreatic Neoplasms
030104 developmental biology
Treatment Outcome
Haplotypes
030220 oncology & carcinogenesis
Multivariate Analysis
Biomarker (medicine)
Female
Polymorphisms
Carcinoma, Pancreatic Ductal
Subjects
Details
- ISSN :
- 1559131X and 13570560
- Volume :
- 34
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Medical oncology (Northwood, London, England)
- Accession number :
- edsair.doi.dedup.....5866e0274ee4b405e8d50344e6209c38