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Cardiac teratogenicity of trichloroethylene metabolites
- Source :
- Journal of the American College of Cardiology. 32(2):540-545
- Publication Year :
- 1998
- Publisher :
- Elsevier BV, 1998.
-
Abstract
- Objectives. The hypothesis of this study was that metabolites of trichloroethylene (TCE), dichloroethylene (DCE) and related compounds were responsible for fetal cardiac teratogenic effects seen when TCE or DCE is consumed by pregnant rats during organogenesis. Identification of teratogenic metabolites would allow more accurate assessment of environmental contaminants and public health risks from contaminated water or possibly municipal water supplies which, when chlorinated, may produce these potentially dangerous chemicals.Background. Human epidemiologic studies and previous teratogenic studies using chick embryos and fetal rats have shown an increased incidence of congenital cardiac lesions in animals exposed to TCE and DCE.Methods. Metabolites and compounds studied in drinking water exposure included: trichloroacetic acid (TCAA), monochloroacetic acid (MCAA), trichloroethanol (TCEth), carboxy methylcystine (CMC), trichloroacetaldehyde (TCAld), dichloroacetaldehyde (DCAld), and dichlorovinyl cystine (DCVC). Compounds were administered to pregnant rats during fetal heart development.Results. Fetuses of rats receiving 2,730 ppm TCAA in drinking water were the only group that demonstrated a significant increase in cardiac defects (10.53%) compared with controls (2.15%) on a per fetus basis (p = 0.0001, Fischer’s exact test), and a per litter basis (p = 0.0004, Wilcoxon and p = 0.0015, exact permutation tests). Trichloroacetic acid also demonstrated an increased number of implantation and resorption sites (p < 0.05) over controls. Other maternal and fetal variables showed no statistically significant differences between treated and untreated groups.Conclusions. Of the metabolites tested, only TCAA appeared to be a specific cardiac teratogen in the fetus when imbibed by the maternal rat.
- Subjects :
- Heart Defects, Congenital
medicine.medical_specialty
Trichloroethylene
Metabolite
Cystine
Ethylene Chlorohydrin
Acetaldehyde
Acetates
010501 environmental sciences
01 natural sciences
Rats, Sprague-Dawley
Embryonic and Fetal Development
03 medical and health sciences
chemistry.chemical_compound
Pregnancy
Water Supply
Internal medicine
medicine
Animals
Humans
Chloral Hydrate
Trichloroacetic Acid
Trichloroacetic acid
030304 developmental biology
0105 earth and related environmental sciences
0303 health sciences
Fetus
business.industry
Abnormalities, Drug-Induced
Heart
Teratology
Dichloroethylenes
Rats
3. Good health
Resorption
Teratogens
Endocrinology
chemistry
Maternal Exposure
Prenatal Exposure Delayed Effects
embryonic structures
Toxicity
Environmental Pollutants
Female
business
Cardiology and Cardiovascular Medicine
Water Pollutants, Chemical
Subjects
Details
- ISSN :
- 07351097
- Volume :
- 32
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Journal of the American College of Cardiology
- Accession number :
- edsair.doi.dedup.....5844ccc71f9221c089fc99d1bdb2b0ca
- Full Text :
- https://doi.org/10.1016/s0735-1097(98)00232-0