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In vivo bronchial epithelial interferon responses are augmented in asthma on day 4 following experimental rhinovirus infection
- Source :
- Thorax. 77(9)
- Publication Year :
- 2021
-
Abstract
- Despite good evidence of impaired innate antiviral responses in asthma, trials of inhaled interferon-β given during exacerbations showed only modest benefits in moderate/severe asthma. Using human experimental rhinovirus infection, we observe robust in vivo induction of bronchial epithelial interferon response genes 4 days after virus inoculation in 25 subjects with asthma but not 11 control subjects. This signature correlated with virus loads and lower respiratory symptoms. Our data indicate that the in vivo innate antiviral response is dysregulated in asthma and open up the potential that prophylactic rather than therapeutic interferon therapy may have greater clinical benefit.
- Subjects :
- Pulmonary and Respiratory Medicine
Science & Technology
Picornaviridae Infections
Rhinovirus
TYPE-2 INFLAMMATION
VIRAL-INFECTIONS
Respiratory System
1103 Clinical Sciences
Epithelial Cells
Innate Immunity
Asthma
Immunity, Innate
respiratory tract diseases
Asthma Mechanisms
Viral infection
Humans
Interferons
Life Sciences & Biomedicine
Subjects
Details
- ISSN :
- 14683296
- Volume :
- 77
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Thorax
- Accession number :
- edsair.doi.dedup.....58413066b5e49fba14b7119a409afd55