Additional file 1 of CDK7 inhibition augments response to multidrug chemotherapy in pancreatic cancer

Additional file 1: Figure S1. A kinome-wide CRISPR screen in pancreatic cancer cells. Figure S2. Targeted inhibition of CDK7 enhances gemcitabine and paclitaxel chemotherapy response in pancreatic cancer in vitro and in vivo. Figure S3. CDK7 inhibition induces cell cycle arrest, apoptotic cell death, and DNA damage. Figure S4. Targeted inhibition of CDK7 reverses chemoresistance in pancreatic cancer. Table S1. Cell lines. Table S2. Plasmids and primers list. Table S3. Antibody list. Table S4. List of CRISPR-Cas9 screening results of gemcitabine and paclitaxel in TB32047 cells.