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Mechanism of the unique susceptibility of deep cortical glomeruli of maturing kidneys to severe focal glomerular sclerosis
- Source :
- Pediatric research. 28(3)
- Publication Year :
- 1990
-
Abstract
- The alterations in single glomerular hemodynamics, glomerular size, and development of glomerular sclerosis after subtotal nephrectomy were assessed in approximately 32-d-old young and greater than 3-mo-old adult Munich-Wistar rats. In 6 wk, young rats developed more pronounced glomerular sclerosis and more marked elevation in blood urea nitrogen. The deep (versus superficial) cortical region of young rats was characterized by having a greater number of glomeruli with advanced sclerosis. Single nephron glomerular filtration rate of superficial glomeruli of the young increased to a much greater extent than whole kidney glomerular filtration rate, whereas there were comparable post-subtotal nephrectomy increases in whole kidney glomerular filtration rate in these two age groups, indicating that the deep glomeruli were exposed to a lesser hemodynamic load than were the superficial. Since the remnant nephrons of young and adult rats achieved equally high glomerular pressures and comparably large glomerular size shortly after subtotal nephrectomy, the unique susceptibility of young glomeruli to sclerosis is attributed to the intrinsic property of these glomeruli, rather than the abnormal hemodynamics or stimuli promoting hypertrophy and mesangial matrix accumulation imposed upon the glomeruli.
- Subjects :
- Male
medicine.medical_specialty
Kidney Cortex
medicine.medical_treatment
Kidney Glomerulus
Renal function
Hemodynamics
Subtotal nephrectomy
urologic and male genital diseases
Nephrectomy
Muscle hypertrophy
Internal medicine
Medicine
Animals
Blood urea nitrogen
Kidney
urogenital system
business.industry
Glomerulosclerosis, Focal Segmental
Age Factors
Glomerulosclerosis
Rats, Inbred Strains
medicine.disease
Rats
Endocrinology
medicine.anatomical_structure
Pediatrics, Perinatology and Child Health
business
Glomerular Filtration Rate
Subjects
Details
- ISSN :
- 00313998
- Volume :
- 28
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pediatric research
- Accession number :
- edsair.doi.dedup.....58213b6676dd4d155866984114aef07c