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Uncialamycin, a New Enediyne Antibiotic
- Source :
- ChemInform. 37
- Publication Year :
- 2006
- Publisher :
- Wiley, 2006.
-
Abstract
- [structure: see text] Laboratory cultures of an undescribed streptomycete obtained from the surface of a British Columbia lichen produce uncialamycin (1), a new enediyne antibiotic. The structure of uncialamycin (1) has been elucidated by analysis of spectroscopic data. Uncialamycin (1) exhibits potent in vitro antibacterial activity against gram-positive and gram-negative human pathogens, including Burkholderia cepacia, a major cause of morbidity and mortality in patients with cystic fibrosis.
- Subjects :
- Cystic Fibrosis
Stereochemistry
medicine.drug_class
Antibiotics
Uncialamycin
Anthraquinones
Human pathogen
Burkholderia cepacia
Biochemistry
Cystic fibrosis
Microbiology
medicine
Enediyne
Humans
In patient
Physical and Theoretical Chemistry
Bacteria
Molecular Structure
biology
Chemistry
Organic Chemistry
General Medicine
biology.organism_classification
medicine.disease
Streptomyces
Anti-Bacterial Agents
Burkholderia
Antibacterial activity
Subjects
Details
- ISSN :
- 15222667 and 09317597
- Volume :
- 37
- Database :
- OpenAIRE
- Journal :
- ChemInform
- Accession number :
- edsair.doi.dedup.....5818c5e7760bd2f8db19919d4f0eb429