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Cryptogenic small‐fiber neuropathies: Serum autoantibody binding to trisulfated heparan disaccharide and fibroblast growth factor receptor‐3
- Source :
- Muscle & Nerve. 61:512-515
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- Introduction Causes of small-fiber peripheral neuropathies (SFN) are often undefined. In this study we investigated associations of serum autoantibodies, immunoglobulin G (IgG) vs fibroblast growth factor receptor-3 (FGFR-3), and immunoglobulin M (IgM) vs trisulfated heparan disaccharide (TS-HDS) in cryptogenic SFN. Methods One hundred fifty-five patients with biopsy-proven SFN and no identified cause for their neuropathy were blindly tested for serum IgM vs TS-HDS and IgG vs FGFR-3. Results Forty-eight percent of SFN patients had serum antibodies, 37% with IgM vs TS-HDS and 15% with IgG vs FGFR-3. TS-HDS antibodies were more frequent in SFN patients than in controls (P = .0012). Both antibodies were more common in females, and with non-length-dependent nerve pathology. Nintey-two percent of patients with acute-onset SFN had serum IgM vs TS-HDS. Discussion Autoantibodies directed against TS-HDS and FGFR-3 suggest an immune disorder in otherwise idiopathic SFN. Serum IgM vs TS-HDS may be a marker for SFN with an acute onset.
- Subjects :
- Male
0301 basic medicine
Physiology
Small Fiber Neuropathy
030105 genetics & heredity
Fibroblast growth factor
Immunoglobulin G
Pathogenesis
03 medical and health sciences
Cellular and Molecular Neuroscience
0302 clinical medicine
Physiology (medical)
Humans
Receptor, Fibroblast Growth Factor, Type 3
Medicine
Autoantibodies
biology
business.industry
Autoantibody
Fibroblast growth factor receptor 3
medicine.disease
Immunoglobulin M
Immunology
biology.protein
Female
Neurology (clinical)
Immune disorder
Antibody
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 10974598 and 0148639X
- Volume :
- 61
- Database :
- OpenAIRE
- Journal :
- Muscle & Nerve
- Accession number :
- edsair.doi.dedup.....5810df25fec535c176f66bbfb0c1ad1e