Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML

Authors :: Birgitte S, Preiss
Olav J, Bergmann
Olav J, Bergman
Lone S, Friis
Anne G, Sørensen
Michael, Frederiksen
Ole V, Gadeberg
Torben, Mourits-Andersen
Birthe, Oestergaard
Gitte B, Kerndrup
Hanne, Vestergaard
Source :: Preiss, B S, Bergman, O J, Friis, L S, Sørensen, A, Frederiksen, M, Gadeberg, O V, Mourits-Andersen, T, Østergaard, B, Kerndrup, G B & AML Study Group of Southern Denmark 2010, ' Cytogenetic findings in adult secondary acute myeloid leukemia (AML): frequency of favorable and adverse chromosomal aberrations do not differ from adult de novo AML ', Cancer Genetics and Cytogenetics, vol. 202, no. 2, pp. 108-22 . https://doi.org/10.1016/j.cancergencyto.2010.06.013
Publication Year :: 2010
Publisher :: Elsevier BV, 2010.
Abstract: During a 15-year period, 161 adult patients were diagnosed with secondary acute myeloid leukemia (s-AML) in the region of Southern Denmark. In 73 patients, the AML diagnosis was preceded by myelodysplastic syndrome (MDS-AML), in 31 patients by an antecedent hematologic disease, and in 57 patients by treatment with chemotherapy and/or irradiation (t-AML). Cytogenetic analysis was carried out in 93%, of which 61% had clonal chromosome aberrations. MDS-AML correlated to a normal karyotype (P

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