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Nitric oxide in preeclampsia: lack of evidence for decreased production
- Publication Year :
- 1998
- Publisher :
- ELSEVIER SCI IRELAND LTD, 1998.
-
Abstract
- The purpose of our study was to determine the involvement of the L-arginine-NO system in preeclampsia. We studied 26 patients with preeclampsia and 27 normotensive pregnancies. Maternal and cord plasma, urine and amniotic fluid were assayed for nitric oxide metabolites (nitrite and nitrate) using the Griess reaction. Sections of placenta and fetal membranes were immunostained with polyclonal anti-endothelial and anti-neuronal nitric oxide synthase antibodies. The concentration of nitrate in the amniotic fluid of preeclamptic patients (median 10.3 mumol/mg creatinine) was significantly higher (P0.001) than in the normotensive group (5.6 mumol/mg creatinine). Nitrate concentrations in maternal and cord plasma and in urine were similar in the two groups. Endothelial cells of the villi of preeclamptic placentas showed a higher positivity in endothelial nitric oxide synthase immunostaining with respect to normotensive controls. Our results indicate that feto-placental NO production is not reduced in preeclampsia. In contrast, the increased concentrations of NO metabolites in amniotic fluid and the positive immunostaining of endothelial nitric oxide synthase in the placental villi suggest that the placental L-arginine-NO system is up-regulated in preeclampsia.
- Subjects :
- Adult
medicine.medical_specialty
Amniotic fluid
Placenta
Extraembryonic Membranes
Arginine
Nitric oxide
Preeclampsia
nitric oxide
placenta and fetal membranes
amniotic fluid
preeclampsia
chemistry.chemical_compound
Pre-Eclampsia
Pregnancy
Internal medicine
Blood plasma
medicine
Humans
Nitrite
reproductive and urinary physiology
Neurons
Creatinine
Nitrates
biology
business.industry
Obstetrics and Gynecology
Fetal Blood
medicine.disease
Nitric oxide synthase
medicine.anatomical_structure
Endocrinology
Reproductive Medicine
chemistry
embryonic structures
biology.protein
Female
Endothelium, Vascular
Nitric Oxide Synthase
business
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....57feb71f10b43fe6907178490a963f16