Advances in Ewing's sarcoma research: Where are we now and what lies ahead?

Ewing's sarcoma family tumors (EFT) are characterized by specific chromosomal translocations, which lead to EWS/ETS transcription factors.Elucidation of EWS/ETS target gene networks within the context of other signaling pathways, together with the identification of the initiating cell, and the development of genetically engineered mice will hopefully lead to biology-based therapeutic strategies for these tumors. 2009 American Association for Cancer Research.
Grant support: The Centro de Investigación del Cáncer participates in EuroBoNeT, the European research network on bone tumors (FP6-2004-Lifescihealth-5, proposal number 018814)-European Commission. The Laboratory of Molecular Pathology of Sarcomas is also supported by the Spanish Ministry of Science and Innovation (FIS-FEDER, PI081828)and by the Junta de Castilla y León (SAN 673/SA 37/08). J. L. Ordóñez is supported by ISCIII (Contratos Perfeccionamiento CD6/00001); D. Osuna is supported by EuroBoNeT; J. Madoz-Gúrpide is supported by the Spanish Ministry of Science and Innovation, Ramón y Cajal Program.