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A Fully Attenuated Recombinant Salmonid Alphavirus Becomes Pathogenic through a Single Amino Acid Change in the E2 Glycoprotein
- Source :
- Journal of Virology, Journal of Virology, American Society for Microbiology, 2013, 87 (10), pp.6027-6030. ⟨10.1128/JVI.03501-12⟩
- Publication Year :
- 2013
- Publisher :
- American Society for Microbiology, 2013.
-
Abstract
- A recombinant sleeping disease virus (rSDV) was previously shown to be totally attenuated and provide long-term protection in trout (C. Moriette, M. Leberre, A. Lamoureux, T. L. Lai, M. Brémont, J. Virol. 80:4088–4098, 2006). Sequence comparison of the rSDV to wild-type genomes exhibited a number of nucleotide changes. In the current study, we demonstrate that the virulent phenotype of SDV was essentially associated with two amino acid changes, V8A and M136T, in the E2 glycoprotein, with the V8A change mostly being involved in the acquisition of the virulent phenotype.
- Subjects :
- Trout
Virulence Factors
Sequence analysis
[SDV]Life Sciences [q-bio]
DNA Mutational Analysis
Molecular Sequence Data
Immunology
Mutation, Missense
RAINBOW-TROUT
Virulence
Alphavirus
Biology
Microbiology
Virus
law.invention
Fish Diseases
Viral Proteins
03 medical and health sciences
law
Virology
Animals
Glycoproteins
030304 developmental biology
chemistry.chemical_classification
0303 health sciences
030306 microbiology
Sequence Analysis, DNA
ENVELOPE GLYCOPROTEIN
biology.organism_classification
Survival Analysis
Phenotype
SLEEPING DISEASE VIRUS
3. Good health
Amino acid
Disease Models, Animal
Amino Acid Substitution
chemistry
Insect Science
Recombinant DNA
Pathogenesis and Immunity
sense organs
Glycoprotein
Subjects
Details
- ISSN :
- 10985514 and 0022538X
- Volume :
- 87
- Database :
- OpenAIRE
- Journal :
- Journal of Virology
- Accession number :
- edsair.doi.dedup.....57fb5d8d0296f98028693c9b449458ba