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Automated Texture Analysis and Determination of Fibre Orientation of Heart Tissue: A Morphometric Study
- Source :
- PLoS ONE, PLoS ONE, Vol 11, Iss 8, p e0160735 (2016)
- Publication Year :
- 2016
-
Abstract
- The human heart has a heterogeneous structure, which is characterized by different cell types and their spatial configurations. The physical structure, especially the fibre orientation and the interstitial fibrosis, determines the electrical excitation and in further consequence the contractility in macroscopic as well as in microscopic areas. Modern image processing methods and parameters could be used to describe the image content and image texture. In most cases the description of the texture is not satisfying because the fibre orientation, detected with common algorithms, is biased by elements such as fibrocytes or endothelial nuclei. The goal of this work is to figure out if cardiac tissue can be analysed and classified on a microscopic level by automated image processing methods with a focus on an accurate detection of the fibre orientation. Quantitative parameters for identification of textures of different complexity or pathological attributes inside the heart were determined. The focus was set on the detection of the fibre orientation, which was calculated on the basis of the cardiomyocytes' nuclei. It turned out that the orientation of these nuclei corresponded with a high precision to the fibre orientation in the image plane. Additionally, these nuclei also indicated very well the inclination of the fibre.
- Subjects :
- 0301 basic medicine
Image Processing
Cell Membranes
lcsh:Medicine
030204 cardiovascular system & hematology
Epithelium
Automation
0302 clinical medicine
Image texture
Myofibrils
Animal Cells
Image Processing, Computer-Assisted
Medicine and Health Sciences
Myocytes, Cardiac
lcsh:Science
Connective Tissue Cells
Staining
Multidisciplinary
Basis (linear algebra)
Orientation (computer vision)
Heart
Image plane
Connective Tissue
Engineering and Technology
Rabbits
Cellular Types
Anatomy
Cellular Structures and Organelles
Biological system
Algorithms
Research Article
Materials science
Imaging Techniques
Muscle Tissue
Image processing
Research and Analysis Methods
Texture (geology)
03 medical and health sciences
Physical structure
Animals
Muscle Cells
Myocardium
lcsh:R
Biology and Life Sciences
Endothelial Cells
Epithelial Cells
Cell Biology
Fibroblasts
Nuclear Staining
030104 developmental biology
Biological Tissue
Specimen Preparation and Treatment
Signal Processing
Cardiovascular Anatomy
lcsh:Q
Focus (optics)
Subjects
Details
- ISSN :
- 19326203
- Volume :
- 11
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- PloS one
- Accession number :
- edsair.doi.dedup.....57f5c0eef11e24406d6f7acd2c821ec6