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Thrombophilic families with inheritably associated high levels of coagulation factors VIII, IX and XI
- Source :
- Journal of Thrombosis and Haemostasis. 1:2134-2139
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- Summary. We describe six families in which associated high levels of coagulation factors (F) XI, FIX and FVIII (each with a plasma concentration higher than the 95th percentile found in a control group of 500 asymptomatic individuals: respectively, 135, 145 and 155 IU dL−1) were inherited as a dominant autosomic genetic traits. In these six families, this syndrome is associated with venous thromboembolic events (Odds ratio 41 [4.9–353], P = 0.0006). It seems to predispose to idiopathic events and, as age increases, is often associated with recurrence. First thrombotic episodes occur in young patients (50% of the carriers are symptomatic at the age of 32 years) and in women, can be unmasked by hormonal treatments, mainly oral contraceptives. The association of high levels of coagulation FXI, FIX and FVIII is thus a new rare high-risk inherited thrombophilia syndrome.
- Subjects :
- Adult
Male
medicine.medical_specialty
Time Factors
Adolescent
Genetic traits
Thrombotic episodes
Gastroenterology
Asymptomatic
Disease-Free Survival
Protein S
Factor IX
Thromboembolism
Internal medicine
Odds Ratio
Humans
Thrombophilia
Medicine
Inherited thrombophilia
Factor XI
Aged
Genes, Dominant
Aged, 80 and over
Family Health
Factor VIII
business.industry
Anticoagulants
Hematology
Odds ratio
Middle Aged
Pedigree
Surgery
Coagulation
Plasma concentration
Female
medicine.symptom
business
Protein C
Hormone
Subjects
Details
- ISSN :
- 15387836
- Volume :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Thrombosis and Haemostasis
- Accession number :
- edsair.doi.dedup.....57f54a39ad3575c7bf5474d8d1e04471