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Understanding the Localization of Berylliosis: Interaction of Be 2+ with Carbohydrates and Related Biomimetic Ligands
- Source :
- Chemistry (Weinheim an Der Bergstrasse, Germany)
- Publication Year :
- 2019
- Publisher :
- Wiley, 2019.
-
Abstract
- The interplay of metal ions with polysaccharides is important for the immune recognition in the lung. Due to the localization of beryllium associated diseases to the lung, it is likely that beryllium carbohydrate complexes play a vital role for the development of berylliosis. Herein, we present a detailed study on the interaction of Be2+ ions with fructose and glucose as well as simpler biomimetic ligands, which emulate binding motives of saccharides. Through NMR and IR spectroscopy as well as single‐crystal X‐ray diffraction, complemented by competition reactions we were able to determine a distinctive trend in the binding affinity of these ligands. This suggests that under physiological conditions beryllium ions are only bound irreversibly in glycoproteins or polysaccharides if a quasi ideal tetrahedral environment and κ4‐coordination is provided by the respective biomolecule. Furthermore, Lewis acid induced conversions of the ligands and an extreme increase in the Brønstedt acidity of the present OH‐groups imply that upon enclosure of Be2+, alterations may be induced by the metal ion in glycoproteins or polysaccharides. In addition the frequent formation of Be‐O‐heterocycles indicates that multinuclear beryllium compounds might be the actual trigger of berylliosis. This investigation on beryllium coordination chemistry was supplemented by binding studies of selected biomimetic ligands with Al3+, Zn2+, Mg2+, and Li+, which revealed that none of these beryllium related ions was tetrahedrally coordinated under the give conditions. Therefore, studies on the metabolization of beryllium compounds cannot be performed with other hard cations as a substitute for the hazardous Be2+.<br />Beryllium chemistry: A detailed study on the interaction of saccharide‐mimicking ligands with Be2+ delivered the first comprehensive knowledge on the preferred binding environment around Be ions in polysaccharides and glycoproteins (see graphic). Additional experiments enabled elucidation of beryllium‐induced alterations in biomolecules, which sheds light on the biochemical mechanisms liable for the development of berylliosis.
- Subjects :
- Main‐Group Chemistry
Magnetic Resonance Spectroscopy
Berylliosis
Metal ions in aqueous solution
Carbohydrates
Molecular Conformation
diols
chemistry.chemical_element
Ligands
010402 general chemistry
01 natural sciences
Catalysis
Coordination complex
Metal
Biomimetic Materials
medicine
Lewis acids and bases
Ions
chemistry.chemical_classification
Full Paper
010405 organic chemistry
Biomolecule
Organic Chemistry
General Chemistry
Full Papers
beryllium
medicine.disease
Combinatorial chemistry
main-group chemistry
0104 chemical sciences
respiratory tract diseases
chemistry
Beryllium Compound
visual_art
coordination chemistry
visual_art.visual_art_medium
Beryllium
Subjects
Details
- ISSN :
- 15213765 and 09476539
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Chemistry – A European Journal
- Accession number :
- edsair.doi.dedup.....57f451d9199da60c23f8970351122184