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Interleukin-17A is involved in enhancement of tumor progression in murine intestine
- Source :
- Immunobiology. 217:54-60
- Publication Year :
- 2012
- Publisher :
- Elsevier BV, 2012.
-
Abstract
- Interleukin (IL)-17A is a cytokine involved in neutrophilic inflammation but the role of IL-17A in anti-tumor immunity is controversial because both pro- and anti-tumor activities of IL-17A have been reported. We hypothesized that constitutive expression of IL-17A in intestinal environment modifies tumor growth. To address the issue, mice were inoculated into subserosa of cecum (i.c.) with murine EL4 lymphoma expressing a model tumor antigen, and tumor growth was monitored. IL-17A-producing cells were detected both in tumor mass and in normal intestinal tissue of i.c. tumor-bearing wild type mice. Tumor size in the wild-type mice was significantly higher than that in the cecum of IL-17A gene-knockout mice. Furthermore, anti-IL-17A monoclonal antibody treatment of wild-type mice resulted in decreased tumor size in the cecum. Model tumor-antigen-specific interferon-γ production was not modified in draining mesenteric lymph node cells in the absence or after neutralization of IL-17A. All the results suggest that constitutive expression of IL-17A in intestine enhances tumor growth, and anti-IL-17A antibody treatment is a candidate of a new anti-tumor immunotherapy against intestinal tumors.
- Subjects :
- Pathology
medicine.medical_specialty
Lymphoma
medicine.medical_treatment
Immunology
Gene Expression
Biology
Interferon-gamma
Mice
Cecum
Serous Membrane
Intestinal Neoplasms
Biomarkers, Tumor
medicine
Animals
Immunology and Allergy
Mice, Knockout
Interleukin-17
Interleukin
Hematology
Immunotherapy
Antibodies, Neutralizing
Xenograft Model Antitumor Assays
Tumor antigen
Tumor Burden
Mice, Inbred C57BL
medicine.anatomical_structure
Cytokine
Tumor progression
Subserosa
Interleukin 17
Subjects
Details
- ISSN :
- 01712985
- Volume :
- 217
- Database :
- OpenAIRE
- Journal :
- Immunobiology
- Accession number :
- edsair.doi.dedup.....57f39a3b30959fcae30ce5bb87d5bfca
- Full Text :
- https://doi.org/10.1016/j.imbio.2011.08.002