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Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort
- Source :
- Chew, C 2021, ' Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort ', Rheumatology (Oxford), vol. 60, no. 10, pp. 4737-4747 . https://doi.org/10.1093/rheumatology/keab090, Rheumatology (United Kingdom), 60(10), 4737-4747. Oxford University Press, Rheumatology (Oxford, England), vol 60, iss 10, Rheumatology (Oxford)
- Publication Year :
- 2021
-
Abstract
- Objectives Vitamin D (25(OH)D) deficiency and metabolic syndrome (MetS) may both contribute to increased cardiovascular risk in SLE. We aimed to examine the association of demographic factors, SLE phenotype, therapy and vitamin D levels with MetS and insulin resistance. Methods The Systemic Lupus International Collaborating Clinics (SLICC) enrolled patients recently diagnosed with SLE ( Results Of the 1847 patients, 1163 (63%) had vitamin D measured and 398 (34.2%) subjects were in the lowest 25(OH)D tertile. MetS was present in 286 of 860 (33%) patients whose status could be determined. Patients with lower 25(OH)D were more likely to have MetS and higher HOMA-IR. The MetS components, hypertension, hypertriglyceridemia and decreased high-density lipoprotein (HDL) were all significantly associated with lower 25(OH)D. Increased average glucocorticoid exposure was associated with higher insulin resistance. Conclusions MetS and insulin resistance are associated with lower vitamin D in patients with SLE. Further studies could determine whether vitamin D repletion confers better control of these cardiovascular risk factors and improve long-term outcomes in SLE.
- Subjects :
- Male
Epidemiology
030204 cardiovascular system & hematology
Global Health
Cardiovascular
Gastroenterology
Cohort Studies
0302 clinical medicine
Lupus Erythematosus, Systemic
Pharmacology (medical)
Vitamin D
Metabolic Syndrome
Diabetes
Clinical Science
Cardiovascular disease
3. Good health
Cohort
Public Health and Health Services
Female
Glucocorticoid
medicine.drug
Adult
medicine.medical_specialty
Clinical Sciences
Immunology
Lupus
Autoimmune Disease
Young Adult
03 medical and health sciences
Insulin resistance
Systemic lupus erythematosus
Rheumatology
Clinical Research
Internal medicine
medicine
Vitamin D and neurology
Humans
Metabolic and endocrine
Nutrition
030203 arthritis & rheumatology
Lupus Erythematosus
business.industry
Systemic
Hypertriglyceridemia
Vitamin D Deficiency
medicine.disease
Arthritis & Rheumatology
Cross-Sectional Studies
Insulin Resistance
Metabolic syndrome
business
Subjects
Details
- Language :
- English
- ISSN :
- 14620324
- Database :
- OpenAIRE
- Journal :
- Chew, C 2021, ' Lower vitamin D is associated with metabolic syndrome and insulin resistance in systemic lupus: data from an international inception cohort ', Rheumatology (Oxford), vol. 60, no. 10, pp. 4737-4747 . https://doi.org/10.1093/rheumatology/keab090, Rheumatology (United Kingdom), 60(10), 4737-4747. Oxford University Press, Rheumatology (Oxford, England), vol 60, iss 10, Rheumatology (Oxford)
- Accession number :
- edsair.doi.dedup.....57efb1960ae1ff5aed7ef333b6edb234