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Influence of Vancomycin Minimum Inhibitory Concentration on the Outcome of Methicillin-Susceptible Staphylococcus aureus Left-Sided Infective Endocarditis Treated with Anti-staphylococcal Beta-Lactam Antibiotics; a Prospective Cohort Study by the International Collaboration on Endocarditis

Authors :
Athan, E.
Harris, O.
Korman, T. M.
Kotsanas, D.
Jones, P.
Reinbott, P.
Ryan, S.
Fortes, C. Q.
Garcia, P.
Jones, S. B.
Barsic, B.
Bukovski, S.
Selton-Suty, C.
Aissa, N.
Doco-Lecompte, T.
Delahaye, F.
Vandenesch, F.
Tattevin, P.
Hoen, B.
Plesiat, P.
Giamarellou, H.
Giannitsioti, E.
Tarpatzi, E.
Durante-Mangoni, E.
Iossa, D.
Orlando, S.
Ursi, M. P.
Pafundi, P. C.
D' Amico, F.
Bernardo, M.
Cuccurullo, S.
Dialetto, G.
Covino, F. E.
Manduca, S.
Della Corte, A.
De Feo, M.
Tripodi, M. F.
Baban, T.
Kanafani, Z. A.
Kanj, S. S.
Sfeir, J.
Yasmine, M.
Morris, A.
Murdoch, D. R.
Premru, M. M.
Lejko-Zupanc, T.
Almela, M.
Ambrosioni, J.
Azqueta, M.
Brunet, M.
Cervera, C.
De Lazzari, E.
Falces, C.
Fuster, D.
Garcia-de-la-Maria, C.
Garcia-Gonzalez, J.
Gatell, J. M.
Marco, F.
Miro, J. M.
Moreno, A.
Ortiz, J.
Ninot, S.
Pare, J. C.
Pericas, J. M.
Quintana, E.
Ramirez, J.
Sandoval, E.
Sitges, M.
Tolosana, J. M.
Vidal, B.
Vila, J.
Bouza, E.
Rodriguez-Creixems, M.
Ramallo, V.
Bradley, S.
Wray, D.
Steed, L.
Cantey, R.
Peterson, G.
Stancoven, A.
Woods, C.
Corey, G. R.
Reller, L. B.
Fowler, V. G.
Chu, V. H.
Messina, J. A.
Park, L.
Sharma-Kuinkel, B. K.
Carugati, M.
Munoz, P.
Baloch, K.
Dixon, C. C.
Harding, T.
Jones-Richmond, M.
Pappas, P.
Park, L. P.
Redick, T.
Stafford, J.
Anstrom, K.
Bayer, A. S.
Cabell, C. H.
Karchmer, A. W.
Sexton, D. J.
Wang, A.
Chu, V.
Durack, D. T.
Eykyn, S.
Moreillon, P.
Olaison, L.
Raoult, D.
Rubinstein, E.
Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS)
Universitat de Barcelona (UB)
Duke University Medical Center
University of Barcelona
Medical University of South Carolina [Charleston] (MUSC)
American University of Beirut [Beyrouth] (AUB)
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
CHU Pontchaillou [Rennes]
Université de Tsukuba = University of Tsukuba
Pericàs, J M
Messina, J A
Garcia-de-la-Mària, C
Park, L
Sharma-Kuinkel, B K
Marco, F
Wray, D
Kanafani, Z A
Carugati, M
Durante Mangoni, E
Tattevin, P
Chu, V H
Moreno, A
Fowler, V G
Miró, J M
De Feo, Marisa
Athan, E11
Harris, O11
Korman, Tm12
Kotsanas, D13
Jones, P14
Reinbott, P14
Ryan, S14
Fortes, Cq15
Garcia, P16
Jones, Sb16
Barsic, B17
Bukovski, S17
Selton-Suty, C18
Aissa, N18
Doco-Lecompte, T18
Delahaye, F19
Vandenesch, F19
Tattevin, P20
Hoen, B21
Plesiat, P21
Giamarellou, H22
Giannitsioti, E22
Tarpatzi, E22
Durante-Mangoni, E23
Iossa, D23
Orlando, S23
Ursi, Mp23
Pafundi, Pc23
D' Amico, F23
Bernardo, M23
Cuccurullo, S23
Dialetto, G23
Covino, Fe23
Manduca, S23
DELLA CORTE, Alessandro
De Feo, M23
Tripodi, Mf24
Baban, T25
Kanafani, Za25
Kanj, Ss25
Sfeir, J25
Yasmine, M25
Morris, A26
Murdoch, Dr27
Premru, Mm28
Lejko-Zupanc, T28
Almela, M29
Ambrosioni, J29
Azqueta, M29
Brunet, M29
Cervera, C29
De Lazzari, E29
Falces, C29
Fuster, D29
Garcia-de-la-Mària, C29
Garcia-Gonzalez, J29
Gatell, Jm29
Marco, F29
Miró, Jm29
Moreno, A29
Ortiz, J29
Ninot, S29
Paré, Jc29
Pericas, Jm29
Quintana, E29
Ramirez, J29
Sandoval, E29
Sitges, M29
Tolosana, Jm29
Vidal, B29
Vila, J29
Bouza, E30
Muñoz, P
Rodríguez-Créixems, M30
Ramallo, V30
Bradley, S31
Wray, D32
Steed, L32
Cantey, R32
Peterson, G33
Stancoven, A33
Woods, C34
Corey, Gr34
Reller, Lb34
Fowler VG, Jr34
Chu, Vh34
Baloch, K
Chu, Vh
Corey, Gr
Dixon, Cc
Fowler VG, Jr
Harding, T
Jones-Richmond, M
Pappas, P
Park, Lp
Redick, T
Stafford, J
Anstrom, K
Athan, E
Bayer, A
Cabell, Ch
Hoen, B
Karchmer, Aw
Miró, Jm
Murdoch, Dr
Sexton, Dj
Wang, A
Chu, V
Durack, Dt
Eykyn, S
Moreillon, P
Olaison, L
Raoult, D
Rubinstein, E
Sexton, Dj.
Source :
Dipòsit Digital de la UB, Universidad de Barcelona, Clinical Microbiology and Infection, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2017, 23 (8), pp.544-549. ⟨10.1016/j.cmi.2017.01.017⟩
Publication Year :
2017
Publisher :
European Society of Clinical Microbiology and Infectious Diseases, 2017.

Abstract

Objectives: Left-sided methicillin-susceptible Staphylococcus aureus (MSSA) endocarditis treated with cloxacillin has a poorer prognosis when the vancomycin minimum inhibitory concentration (MIC) is >= 1.5 mg/L. We aimed to validate this using the International Collaboration on Endocarditis cohort and to analyse whether specific genetic characteristics were associated with a high vancomycin MIC (> 1.5mg/L) phenotype.Methods: All patients with left-sided MSSA infective endocarditis treated with antistaphylococcal beta-lactam antibiotics between 2000 and 2006 with available isolates were included. Vancomycin MIC was determined by Etest as either high (>= 1.5 mg/L) or low (

Subjects

Subjects :
0301 basic medicine
Male
medicine.disease_cause
0302 clinical medicine
80 and over
Medicaments antibacterians
030212 general & internal medicine
Endocarditi
Prospective Studies
Aged, 80 and over
Endocarditis
Bacterial
General Medicine
Middle Aged
Staphylococcal Infections
3. Good health
Anti-Bacterial Agents
Fenotip
Infectious Diseases
[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology
Treatment Outcome
Phenotype
Staphylococcus aureus
Infective endocarditis
Staphylococcus aureu
Vancomycin
Genotype
Vancomycin MIC
Adult
Aged
Endocarditis, Bacterial
Female
Humans
Microbial Sensitivity Tests
Molecular Typing
Multiplex Polymerase Chain Reaction
Survival Analysis
Virulence Factors
beta-Lactams
medicine.drug
Microbiology (medical)
030106 microbiology
Biology
Staphylococcal infections
Article
Microbiology
03 medical and health sciences
Minimum inhibitory concentration
medicine
Etest
Endocarditis Staphylococcus aureus
biochemical phenomena, metabolism, and nutrition
medicine.disease
Antibacterial agents
Methicillin Susceptible Staphylococcus Aureus

Details

ISSN :
1198743X and 14690691
Database :
OpenAIRE
Journal :
Dipòsit Digital de la UB, Universidad de Barcelona, Clinical Microbiology and Infection, Clinical Microbiology and Infection, Elsevier for the European Society of Clinical Microbiology and Infectious Diseases, 2017, 23 (8), pp.544-549. ⟨10.1016/j.cmi.2017.01.017⟩
Accession number :
edsair.doi.dedup.....57ef66d50a93ee41e9580c978d8cde9c

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Authors Abstract Subjects Details