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Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans
- Source :
- Pharmaceutics, Volume 13, Issue 2, Okonogi, S, Phumat, P, Khongkhunthian, S, Chaijareenont, P, Rades, T & Mullertz, A 2021, ' Development of Self-Nanoemulsifying Drug Delivery Systems Containing 4-Allylpyrocatechol for Treatment of Oral Infections Caused by Candida albicans ', Pharmaceutics, vol. 13, no. 2, 167 . https://doi.org/10.3390/pharmaceutics13020167, Pharmaceutics, Vol 13, Iss 167, p 167 (2021)
- Publication Year :
- 2021
- Publisher :
- Multidisciplinary Digital Publishing Institute, 2021.
-
Abstract
- Clinical use of 4-Allylpyrocatechol (APC), a potential antifungal agent from Piper betle, is limited because of its low water solubility. The current study explores the development of the self-nanoemulsifying drug delivery system (SNEDDS) containing APC (APC-SNEDDS) to enhance APC solubility. Results demonstrated that excipient type and concentration played an important role in the solubility of APC in the obtained SNEEDS. SNEDDS, comprising 20% Miglyol 812N, 30% Maisine 35-1, 40% Kolliphor RH40, and 10% absolute ethanol, provided the highest loading capacity and significantly increased water solubility of APC. Oil-in-water nanoemulsions (NE) with droplet sizes of less than 40 nm and a narrow size distribution were obtained after dispersing this APC-SNEDDS in water. The droplets had a negative zeta potential between &minus<br />10 and &minus<br />20 mV. The release kinetics of APC from APC-SNEDDS followed the Higuchi model. The NE containing 1.6 mg APC/mL had effective activity against Candida albicans with dose-dependent killing kinetics and was nontoxic to normal cells. The antifungal potential was similar to that of 1 mg nystatin/mL. These findings suggest that APC-SNEDDS are a useful system to enhance the apparent water solubility of APC and are a promising system for clinical treatment of oral infection caused by C. albicans.
- Subjects :
- Pharmaceutical Science
Excipient
lcsh:RS1-441
02 engineering and technology
Pharmacology
030226 pharmacology & pharmacy
lcsh:Pharmacy and materia medica
03 medical and health sciences
0302 clinical medicine
Candida albicans
medicine
Zeta potential
Distribution (pharmacology)
Solubility
biology
Chemistry
antifungal activity
021001 nanoscience & nanotechnology
biology.organism_classification
4-allylpyrocatechol
Corpus albicans
Nystatin
solubility enhancement
oral infections
Drug delivery
SNEDDS
0210 nano-technology
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 19994923
- Database :
- OpenAIRE
- Journal :
- Pharmaceutics
- Accession number :
- edsair.doi.dedup.....57e6332fcd26fca17121e6e4bf7df47f
- Full Text :
- https://doi.org/10.3390/pharmaceutics13020167