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Genetic polymorphisms in glutathione-S-transferases are associated with anxiety and mood disorders in nicotine dependence
- Source :
- Psychiatric Genetics
- Publication Year :
- 2014
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2014.
-
Abstract
- Background Nicotine dependence is associated with an increased risk of mood and anxiety disorders and suicide. The primary hypothesis of this study was to identify whether the polymorphisms of two glutathione-S-transferase enzymes (GSTM1 and GSTT1 genes) predict an increased risk of mood and anxiety disorders in smokers with nicotine dependence. Materials and methods Smokers were recruited at the Centre of Treatment for Smokers. The instruments were a sociodemographic questionnaire, Fagerström Test for Nicotine Dependence, diagnoses of mood disorder and nicotine dependence according to DSM-IV (SCID-IV), and the Alcohol, Smoking and Substance Involvement Screening Test. Anxiety disorder was assessed based on the treatment report. Laboratory assessment included glutathione-S-transferases M1 (GSTM1) and T1 (GSTT1), which were detected by a multiplex-PCR protocol. Results Compared with individuals who had both GSTM1 and GSTT1 genes, a higher frequency of at least one deletion of the GSTM1 and GSTT1 genes was identified in anxious smokers [odds ratio (OR)=2.21, 95% confidence interval (CI)=1.05–4.65, P=0.034], but there was no association with bipolar and unipolar depression (P=0.943). Compared with nonanxious smokers, anxious smokers had a greater risk for mood disorders (OR=4.67; 95% CI=2.24–9.92, P
- Subjects :
- Adult
Male
Adolescent
Suicide, Attempted
mood disorder
Bioinformatics
Young Adult
genetic polymorphisms
Genetics
medicine
Humans
anxiety disorder
Genetic Predisposition to Disease
Bipolar disorder
Young adult
nicotine dependence
Biological Psychiatry
Genetics (clinical)
Glutathione Transferase
Polymorphism, Genetic
biology
Mood Disorders
Smoking
glutathione-S-transferase
Tobacco Use Disorder
Original Articles
Middle Aged
medicine.disease
Anxiety Disorders
Psychiatry and Mental health
Glutathione S-transferase
Mood
Mood disorders
biology.protein
Anxiety
Major depressive disorder
Female
medicine.symptom
Psychology
Anxiety disorder
Clinical psychology
Subjects
Details
- ISSN :
- 09558829
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Psychiatric Genetics
- Accession number :
- edsair.doi.dedup.....57cc319bc0f7ec407a9b78b7a009b713