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The impact of folate intake on the risk of head and neck cancer in the prostate, lung, colorectal, and ovarian cancer screening trial (PLCO) cohort
- Source :
- British Journal of Cancer
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Background: Although low levels of folate leads to disturbances in DNA replication, DNA methylation and DNA repair, the association between dietary folate intake and head and neck cancer (HNC) risk remains unclear. Methods: We evaluated the association between folate intake and HNC risk using prospective cohort data from the Prostate, Lung, Colorectal, and Ovarian (PLCO) cancer screening trial. This study included 101 700 participants and 186 cases with confirmed incident HNC. The median follow-up was 12.5 years. We estimated hazard ratios (HRs) and the corresponding 95% confidence intervals (CIs) using Cox proportional hazard model including age, sex, body mass index, education, race, tobacco smoking, alcohol drinking and total fruit and vegetable intake. Results: Higher intake of food folate and fortified folic acid in foods was associated with a decreasing HNC risk in a dose–response manner. The HRs of highest vs the lowest quartile of intake were 0.35 (95%CI: 0.18–0.67) for food folate, and 0.49 (95%CI: 0.30–0.82) for fortified folic acid. Intakes of total folate, natural folate and supplemental folic acid were not associated with the risk of HNC and its subsites. We did not detect any interaction between smoking, drinking and food folate intake on HNC risk. Conclusions: These findings provide evidence of the protective role of dietary folate intake on HNC risk.
- Subjects :
- Male
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
Epidemiology
Cohort Studies
03 medical and health sciences
Folic Acid
0302 clinical medicine
Internal medicine
Cancer screening
Humans
Medicine
Prospective Studies
030212 general & internal medicine
Prospective cohort study
Early Detection of Cancer
risk
Aged
Ovarian Neoplasms
2. Zero hunger
fortified folic acid
prospective cohort study
business.industry
Proportional hazards model
Hazard ratio
Head and neck cancer
Prostatic Neoplasms
Middle Aged
medicine.disease
United States
Diet
3. Good health
Head and Neck Neoplasms
030220 oncology & carcinogenesis
supplemental folic acid
Food, Fortified
Cohort
head and neck cancer
Female
food folate
Colorectal Neoplasms
business
Body mass index
Cohort study
Subjects
Details
- ISSN :
- 15321827 and 00070920
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- British Journal of Cancer
- Accession number :
- edsair.doi.dedup.....57c86949233b0edfe17122ccaf5c7c32