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Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma
- Source :
- Molecular Medicine Reports
- Publication Year :
- 2014
- Publisher :
- Spandidos Publications, 2014.
-
Abstract
- The prognosis of patients with osteosarcoma with distant metastasis and local recurrence remains poor. Increased expression of polymeric immunoglobulin receptor (pIgR) in tumor tissue has been detected in various types of cancer. However, the clinical significance of pIgR in osteosarcoma has yet to be elucidated. The present study aimed to investigate the prognostic value of pIgR in patients with osteosarcoma following surgical resection. pIgR expression was assessed using quantitative polymerase chain reaction analysis in cryopreserved osteosarcoma tissues from 22 patients, as well as using immunohistochemistry in paraffin-embedded osteosarcoma tissues from 136 patients. The association between pIgR expression, clinicopathological factors and long-term prognosis was retrospectively examined in these 136 patients. The prognostic significance of negative or positive pIgR expression in osteosarcoma was assessed using Kaplan-Meier survival analysis and log-rank tests. Univariate analysis indicated that patients with positive pIgR osteosarcoma tissue expression had a significantly worse overall survival (OS) compared with patients with negative pIgR osteosarcoma expression. Multivariate analysis revealed that positive pIgR expression in osteosarcoma tissues was an independent prognostic factor for OS following surgical resection (P
- Subjects :
- Adult
Male
musculoskeletal diseases
Oncology
Cancer Research
medicine.medical_specialty
Pathology
Adolescent
Biochemistry
Young Adult
Internal medicine
Genetics
medicine
Humans
Clinical significance
RNA, Messenger
neoplasms
Molecular Biology
Survival analysis
Osteosarcoma
Univariate analysis
business.industry
Receptors, Polymeric Immunoglobulin
Cancer
polymeric immunoglobulin receptor
Articles
Prognosis
medicine.disease
Immunohistochemistry
Molecular medicine
Gene Expression Regulation, Neoplastic
Molecular Medicine
Female
Polymeric immunoglobulin receptor
business
Follow-Up Studies
Subjects
Details
- ISSN :
- 17913004 and 17912997
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Molecular Medicine Reports
- Accession number :
- edsair.doi.dedup.....57bcded59dd528dd1f0209c4f475e725