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Undressing the Fungal Cell Wall/Cell Membrane - the Antifungal Drug Targets
- Source :
- Current Pharmaceutical Design, Current Pharmaceutical Design, 2013, 19 (20), pp.3738-3747. ⟨10.2174/1381612811319200012⟩, Current Pharmaceutical Design, Bentham Science Publishers, 2013, 19 (20), pp.3738-3747. ⟨10.2174/1381612811319200012⟩, ResearcherID
- Publication Year :
- 2013
- Publisher :
- Bentham Science Publishers Ltd., 2013.
-
Abstract
- International audience; Being external, the fungal cell wall plays a crucial role in the fungal life. By covering the underneath cell, it offers mechanical strength and acts as a barrier, thus protecting the fungus from the hostile environment. Chemically, this cell wall is composed of different polysaccharides. Because of their specific composition, the fungal cell wall and its underlying plasma membrane are unique targets for the development of drugs against pathogenic fungal species. The objective of this review is to consolidate the current knowledge on the antifungal drugs targeting the cell wall and plasma membrane, mainly of Aspergillus and Candida species - the most prevalent fungal pathogens, and also to present challenges and questions conditioning the development of new antifungal drugs targeting the cell wall.
- Subjects :
- Antifungal Agents
Cell
Antifungal drug
Fungus
MESH: Drug Design
Polysaccharide
Microbiology
Cell wall
Cell membrane
03 medical and health sciences
MESH: Cell Wall
MESH: Candida
Cell Wall
Polysaccharides
MESH: Molecular Targeted Therapy
Drug Discovery
Mechanical strength
medicine
Animals
Aspergillosis
Humans
MESH: Animals
MESH: Aspergillosis
Molecular Targeted Therapy
[SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology
Candida
030304 developmental biology
Pharmacology
chemistry.chemical_classification
0303 health sciences
Aspergillus
MESH: Humans
biology
030306 microbiology
Cell Membrane
Candidiasis
MESH: Antifungal Agents
biology.organism_classification
MESH: Candidiasis
MESH: Polysaccharides
medicine.anatomical_structure
chemistry
MESH: Aspergillus
Drug Design
[SDV.SP.PHARMA]Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology
MESH: Cell Membrane
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....57b2c97233713e5c5483d18c2cb67aec