Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations

Authors :: Misao Matsushita
Masaya Kawakami
Monika Borkowska-Klos
Anne P.M. Atkinson
Anna St. Swierzko
Jerzy Szczapa
Marc Turner
Agnieszka Szala
Maciej Cedzynski
Jens C. Jensenius
Iwona Domzalska-Popadiuk
Janusz Szemraj
Shirley Lynn Macdonald
David C. Kilpatrick
Aleksandra Jopek
Source :: St Swierzko, A, Cedzynski, M, Domzalska-Popadiuk, I, MacDonald, S L, Borkowska-Klos, M, Atkinson, A P M, Szala, A, Jopek, A, Jensenius, J C, Kawakami, M, Szczapa, J, Matsushita, M, Szemraj, J, Turner, M L & Kilpatrick, D C 2009, ' Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations ', Molecular Immunology, vol. 46, no. 8-9, pp. 1696-701 . https://doi.org/10.1016/j.molimm.2009.02.022
Publication Year :: 2009
Publisher :: Elsevier BV, 2009.
Abstract: Udgivelsesdato: 2009-May One collectin (mannan-binding lectin, MBL) and three ficolins (M-ficolin/ficolin-1, L-ficolin/ficolin-2 and H-ficolin/ficolin-3) share the capability to activate complement via the lectin pathway. This property depends on the ability of these lectins to form complexes with MBL-associated serine proteases (MASPs), particularly MASP-2. We report the results of an investigation of cord blood MASP-2 concentrations in a large, ethnically homogeneous cohort (n=1788) of neonates. The median value of MASP-2 in cord sera was determined to be 93 ng/ml (range

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