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Poly D,L-Lactide-Co-Glycolic Acid Grafting Material in Sinus Lift
- Source :
- The Journal of craniofacial surgery. 30(4)
- Publication Year :
- 2019
-
Abstract
- The poly D,L-lactide-co-glycolic acid (PLGA) is a copolymer used in many therapeutic devices for its high rates of biodegradability and biocompatibility. The principal aim of the research was to evaluate the new bone formation, after 16 (T1) and 28 weeks (T2), in sheep maxillary sinus lift in vivo model using PLGA.Computerized tomography analysis, X-ray microanalysis, and scanning electron microscope analysis of secondary electrons (SE) and the backscattered electrons (BSE) of the samples were detected.After 28 weeks, the computed tomography analysis showed a 22% increase of UH density in the grafting areas. The X-ray microanalysis of the samples showed calcium and phosphorus increase at T1 and T2 follow-up period and the carbon and oxygen concentration decrease. The SE evaluation showed a rapid superficial resorption of the biomaterials at T1 and a completely bone reorganization of biomaterial at T2. The BSE analysis confirmed the SE data and showed the direct and intimate contact between bone and PLGA with a higher calcification in T2 compared to T1.Certainly, still other experiments and a larger number of samples will be necessary to be analyzed to determine the behavior of the PLGA in the bone regeneration; however, the PLGA used in maxillary sinus lift animal model, seem to promote new bone formation that continues increase at 28 weeks after grafting.
- Subjects :
- Sinus Floor Augmentation
Bone Regeneration
Biocompatibility
Sinus lift
Biocompatible Materials
Bone regeneration
Computed tomography evaluation
Poly lactide-co-glycolic acid (PLGA)
Resorbable bone grafts
X-ray microanalysis
Animals
Calcification, Physiologic
Dental Implants
Glycolates
Maxillary Sinus
Models, Animal
Sheep
Tomography, X-Ray Computed
Calcification
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Models
medicine
030223 otorhinolaryngology
Physiologic
Tomography
Glycolic acid
business.industry
Animal
Biomaterial
030206 dentistry
General Medicine
medicine.disease
X-Ray Computed
PLGA
Otorhinolaryngology
chemistry
Surgery
business
Biomedical engineering
Subjects
Details
- ISSN :
- 15363732
- Volume :
- 30
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- The Journal of craniofacial surgery
- Accession number :
- edsair.doi.dedup.....57a9d5dab8f790a90843a5b1d2d0aca9