Back to Search
Start Over
Large-scale mortality gap between SLE and control population is associated with increased infection-related mortality in lupus
- Source :
- Rheumatology (Oxford, England)
- Publication Year :
- 2020
- Publisher :
- Oxford University Press (OUP), 2020.
-
Abstract
- Objective The aim of the present study was to analyse the incidence, prevalence, mortality and cause of death data of adult SLE patients and matched controls in a full-populational, nationwide, retrospective study. Methods This non-interventional study was based on database research of the National Health Insurance Fund of Hungary. A total of 7888 patients were included in the analyses, within which two subgroups of incident patients were created: the ‘All incident SLE patients’ group consisted of all incident SLE patients (4503 patients), while the ‘Treated SLE patients’ group contained those who received relevant therapy in the first 6 months after diagnosis (2582 patients). Results The median age of the SLE population was found to be 46.5 years (women 85%). The incidence rate was 4.86 and 2.78 per 100 000 inhabitants in the ‘All incident SLE patients’ and ‘Treated SLE patients’ groups, respectively. The standardized mortality ratio was 1.63 and 2.09 in the ‘All incident SLE patients’ and ‘Treated SLE patients’ groups, respectively. Overall survival was significantly lower (P Conclusion Infections, especially sepsis, had the largest positive effect on top of the extra mortality of SLE. This highlights that SLE patients are at increased risk of infection-related death.
- Subjects :
- Adult
Male
medicine.medical_specialty
Population
Infections
Sepsis
outcome measures
Young Adult
systemic lupus erythematosus
Rheumatology
immune system diseases
Cause of Death
Neoplasms
Internal medicine
Epidemiology
Prevalence
medicine
Humans
Lupus Erythematosus, Systemic
Pharmacology (medical)
Mortality
skin and connective tissue diseases
education
AcademicSubjects/MED00360
Proportional Hazards Models
Retrospective Studies
Cause of death
Hungary
education.field_of_study
Systemic lupus erythematosus
health policies
business.industry
Incidence
Incidence (epidemiology)
Retrospective cohort study
Pneumonia
Clinical Science
Middle Aged
medicine.disease
Cerebrovascular Disorders
Standardized mortality ratio
statistics
Cardiovascular Diseases
Case-Control Studies
epidemiology
Female
business
Subjects
Details
- ISSN :
- 14620332 and 14620324
- Volume :
- 59
- Database :
- OpenAIRE
- Journal :
- Rheumatology
- Accession number :
- edsair.doi.dedup.....57a2788bd59b7641337dd2336d233ad2