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Thermosensitive gallic acid-conjugated hexanoyl glycol chitosan as a novel wound healing biomaterial
- Source :
- Carbohydrate Polymers. 260:117808
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- In the present study, a novel synthetic tissue adhesive material capable of sealing wounds without the use of any crosslinking agent was developed by conjugating thermosensitive hexanoyl glycol chitosan (HGC) with gallic acid (GA). The degree of N-gallylation was manipulated to prepare GA-HGCs with different GA contents. GA-HGCs demonstrated thermosensitive sol-gel transition behavior and formed irreversible hydrogels upon natural oxidation of the pyrogallol moieties in GA, possibly leading to GA-HGC crosslinks through intra/intermolecular hydrogen bonding and chemical bonds. The GA-HGC hydrogels exhibited self-healing properties, high compressive strength, strong tissue adhesive strength and biodegradability that were adjustable according to the GA content. GA-HGCs also presented excellent biocompatibility and wound healing effects. The results of in vivo wound healing efficacy studies on GA-HGC hydrogels indicated that they significantly promote wound closure and tissue regeneration by upregulating growth factors and recruiting fibroblasts compared to the untreated control group.
- Subjects :
- Compressive Strength
Polymers and Plastics
Biocompatibility
Swine
Biocompatible Materials
02 engineering and technology
Conjugated system
010402 general chemistry
01 natural sciences
chemistry.chemical_compound
Gallic Acid
Materials Chemistry
Animals
Gallic acid
Chitosan
Wound Healing
Organic Chemistry
technology, industry, and agriculture
Biomaterial
Hydrogels
021001 nanoscience & nanotechnology
0104 chemical sciences
chemistry
Chemical engineering
Pyrogallol
Self-healing hydrogels
Tissue Adhesives
Adhesive
Rheology
0210 nano-technology
Wound healing
Subjects
Details
- ISSN :
- 01448617
- Volume :
- 260
- Database :
- OpenAIRE
- Journal :
- Carbohydrate Polymers
- Accession number :
- edsair.doi.dedup.....579bb9456a733ad8100eba7bdd56b9d5