Supplementary Figure S3 from A Phase I Study of LY3009120, a Pan-RAF Inhibitor, in Patients with Advanced or Metastatic Cancer

Supplementary Figure S3 shows a heatmap of gene expression in the scale of log2 fold ratio between pre- and on-treatment tumor samples. The gene expression was obtained using the formula for a gene g: 2^[20-CT_g+HK]/1000 where CT is the cycle threshold used to detect the gene g. HK is the average over the cycle thresholds used to detect the three housekeeping genes: GUSB, PPIB, and PGK1. The columns of the heatmap represent the 11 target genes. The rows are the five patients labeled with their mutation status. The label is missing if a gene test was not done or not available. Abbreviation: RT-PCR, reverse transcriptase polymerase chain reaction.