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Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia
- Source :
- Asian Journal of Andrology, Vol 19, Iss 3, Pp 338-345 (2017), Asian Journal of Andrology
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer Medknow Publications, 2017.
-
Abstract
- The aim of the present work was to present the outcomes of the patients with Y-chromosome microdeletions treated by intracytoplasmic sperm injection (ICSI), either using fresh (TESE) or frozen-thawed (TESE-C) testicular sperm and ejaculated sperm (EJAC). The originality of this work resides in the comparisons between the different types of Y-microdeletions (AZFa, AZFb, and AZFc) and treatments, with detailed demographic, stimulation, embryological, clinical, and newborn (NB) outcomes. Of 125 patients with Y-microdeletions, 33 patients presented severe oligozoospermia (18 performed ICSI with ejaculated sperm) and 92 secretory azoospermia (65 went for TESE with 40 having successful sperm retrieval and performed ICSI). There were 51 TESE treatment cycles and 43 TESE-C treatment cycles, with a birth of 19 NB (2 in AZFa/TESE-C, 12 in AZFc/TESE, and 5 in AZFc/TESE-C). Of the 29 EJAC cycles, there was a birth of 8 NB (in AZFc). In TESE and EJAC cycles, there were no significant differences in embryological and clinical parameters. In TESE-C cycles, there was a significant lower oocyte maturity rate, embryo cleavage rate and mean number of embryos transferred in AZFb, and a higher mean number of oocytes and lower fertilization rate in AZFc. In conclusion, although patients with AZFc microdeletions presented a high testicular sperm recovery rate and acceptable clinical outcomes, cases with AZFa and AZFb microdeletions presented a poor prognosis. Due to the reported heredity of microdeletions, patients should be informed about the infertile consequences on NB and the possibility of using preimplantation genetic diagnosis for female sex selection.
- Subjects :
- Male
newborn outcomes
medicine.medical_treatment
Biopsy
030232 urology & nephrology
intracytoplasmic sperm injection
lcsh:RC870-923
Intracytoplasmic sperm injection
Male infertility
0302 clinical medicine
Pregnancy
nonobstructive azoospermia
Y-chromosome microdeletions
Testis
Medicine
Sex Chromosome Aberrations
Azoospermia
030219 obstetrics & reproductive medicine
Pregnancy Outcome
General Medicine
Middle Aged
Prognosis
Testicular sperm extraction
Original Article
Female
Chromosome Deletion
medicine.medical_specialty
Y chromosome microdeletion
Urology
Cleavage Stage, Ovum
Sex Chromosome Disorders of Sex Development
03 medical and health sciences
Young Adult
severe oligozoospermia
testicular sperm extraction
Humans
Sperm Injections, Intracytoplasmic
Infertility, Male
Retrospective Studies
Gynecology
Chromosomes, Human, Y
business.industry
urogenital system
Infant, Newborn
Oligospermia
medicine.disease
lcsh:Diseases of the genitourinary system. Urology
Sperm
Fertilization
Sperm Retrieval
Oocytes
business
Subjects
Details
- Language :
- English
- ISSN :
- 17457262
- Volume :
- 19
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Andrology
- Accession number :
- edsair.doi.dedup.....576b6b08e9b6d20017d1543ff6e05049