Back to Search
Start Over
Model systems to analyze the role of miRNAs and commensal microflora in bovine mucosal immune system development
- Source :
- Molecular Immunology. 66:57-67
- Publication Year :
- 2015
- Publisher :
- Elsevier BV, 2015.
-
Abstract
- Information is rapidly accumulating regarding the role of miRNAs as key regulators of immune system development and function. It is also increasingly evident that miRNAs play an important role in host-pathogen interactions through regulation of both innate and acquired immune responses. Little is known, however, about the specific role of miRNAs in regulating normal development of the mucosal immune system, especially during the neonatal period. Furthermore, there is limited knowledge regarding the possible role the commensal microbiome may play in regulating mucosal miRNAs expression, although evidence is emerging that a variety of enteric pathogens influence miRNA expression. The current review focuses on recent information that miRNAs play an important role in regulating early development of the bovine mucosal immune system. A possible role for the commensal microbiome in regulating mucosal development by altering miRNA expression is also discussed. Finally, we explore the potential advantages of using the newborn calf as a model to determine how interactions between developmental programming, maternal factors in colostrum, and colonization of the gastrointestinal tract by commensal bacteria may alter mucosal miRNA expression and immune development. Identifying the key factors that regulate mucosal miRNA expression is critical for understanding how the balance between protective immunity and inflammation is maintained to ensure optimal gastrointestinal tract function and health of the whole organism.
- Subjects :
- Protective immunity
Gastrointestinal tract
Bacteria
Colostrum
Immunology
Inflammation
Biology
Intestines
MicroRNAs
Immune system
Animals, Newborn
Gene Expression Regulation
Pregnancy
microRNA
medicine
Animals
Cattle
Female
Microbiome
medicine.symptom
Immunity, Mucosal
Molecular Biology
Developmental programming
Function (biology)
Subjects
Details
- ISSN :
- 01615890
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Molecular Immunology
- Accession number :
- edsair.doi.dedup.....5761495ebfeb3b415f159565d23c8c07