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FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation
- Source :
- PloS one 11 (2016): e0151359. doi:10.1371/journal.pone.0151359, info:cnr-pdr/source/autori:Di Sanzo, Maddalena; Aversa, Ilenia; Santamaria, Gianluca; Gagliardi, Monica; Panebianco, Mariafranca; Biamonte, Flavia; Zolea, Fabiana; Faniello, Maria Concetta; Cuda, Giovanni; Costanzo, Francesco/titolo:FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation/doi:10.1371%2Fjournal.pone.0151359/rivista:PloS one/anno:2016/pagina_da:e0151359/pagina_a:/intervallo_pagine:e0151359/volume:11, PLoS ONE, PLoS ONE, Vol 11, Iss 3, p e0151359 (2016)
- Publication Year :
- 2016
- Publisher :
- Public Library of Science, San Francisco, CA , Stati Uniti d'America, 2016.
-
Abstract
- Ferritin, the major iron storage protein, performs its essential functions in the cytoplasm, nucleus and mitochondria. The variable assembly of 24 subunits of the Heavy (H) and Light (L) type composes the cytoplasmic molecule. In humans, two distinct genes code these subunits, both belonging to complex multigene families. Until now, one H gene has been identified with the coding sequence interrupted by three introns and more than 20 intronless copies widely dispersed on different chromosomes. Two of the intronless genes are actively transcribed in a tissue-specific manner. Herein, we report that FTH1P3, another intronless pseudogene, is transcribed. FTH1P3 transcript was detected in several cell lines and tissues, suggesting that its transcription is ubiquitary, as it happens for the parental ferritin H gene. Moreover, FTH1P3 expression is positively regulated during the cell differentiation process.
- Subjects :
- 0301 basic medicine
Transcription, Genetic
Cellular differentiation
lcsh:Medicine
Gene Expression
Artificial Gene Amplification and Extension
Biochemistry
Polymerase Chain Reaction
0302 clinical medicine
Gene expression
lcsh:Science
Regulation of gene expression
Multidisciplinary
biology
Messenger RNA
FTH1P3
Cell Differentiation
Genomics
Complementary DNA
Nucleic acids
030220 oncology & carcinogenesis
Pseudogenes
Research Article
Forms of DNA
Pseudogene
Molecular Sequence Data
Genome Complexity
Research and Analysis Methods
Cell Line
03 medical and health sciences
Gene Types
Sequence Homology, Nucleic Acid
Genetics
Humans
Molecular Biology Techniques
Non-coding RNA
Gene
Molecular Biology
Base Sequence
lcsh:R
ferritin
Intron
Biology and Life Sciences
Computational Biology
Proteins
Protein Complexes
DNA
Molecular biology
Gene regulation
Ferritin
MicroRNAs
030104 developmental biology
Gene Expression Regulation
Cytoplasm
Ferritins
biology.protein
RNA
lcsh:Q
Developmental Biology
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- PloS one 11 (2016): e0151359. doi:10.1371/journal.pone.0151359, info:cnr-pdr/source/autori:Di Sanzo, Maddalena; Aversa, Ilenia; Santamaria, Gianluca; Gagliardi, Monica; Panebianco, Mariafranca; Biamonte, Flavia; Zolea, Fabiana; Faniello, Maria Concetta; Cuda, Giovanni; Costanzo, Francesco/titolo:FTH1P3, a Novel H-Ferritin Pseudogene Transcriptionally Active, Is Ubiquitously Expressed and Regulated during Cell Differentiation/doi:10.1371%2Fjournal.pone.0151359/rivista:PloS one/anno:2016/pagina_da:e0151359/pagina_a:/intervallo_pagine:e0151359/volume:11, PLoS ONE, PLoS ONE, Vol 11, Iss 3, p e0151359 (2016)
- Accession number :
- edsair.doi.dedup.....5760b84a3fd6b4442fab219a66bdc620
- Full Text :
- https://doi.org/10.1371/journal.pone.0151359