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Role of glial cells, growth factors and steroid hormones in the control of LHRH-secreting neurons
- Source :
- Domestic Animal Endocrinology. 25:101-108
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- The mechanisms through which steroid hormones influence the LHRH system are not completely clarified and still represent a crucial and debated field of research in the neuroendocrine control of reproduction. Several data indicate that glial cells influence the activity of hypothalamic LHRH-secreting neurons, via the release of growth factors. It is now well known that glial cells express different kinds of steroid receptors and consequently may be considered as a target for the action of steroid hormones. To this purpose, the possibility that the effects of steroid hormones on LHRH neurons may be mediated by glial elements has been taken in consideration and observations supporting this hypothesis have been reported and discussed here. The results so far obtained strongly suggest that steroid hormones and growth factors, in order to exert their modulatory actions on LHRH dynamic, act in an integrated manner at the level of hypothalamic astrocytes.
- Subjects :
- medicine.medical_specialty
medicine.medical_treatment
Gonadotropin-releasing hormone
Peptide hormone
Biology
Settore MED/13 - Endocrinologia
Steroid
Gonadotropin-Releasing Hormone
Glial cells
Growth factors
Hypothalamus
LHRH
Steroid hormones
Endocrinology
Food Animals
Internal medicine
medicine
Animals
Testosterone
Growth Substances
Progesterone
Neurons
Estrogens
Sex hormone receptor
Hormones
medicine.anatomical_structure
Neuroglia
Animal Science and Zoology
hormones, hormone substitutes, and hormone antagonists
Hormone
Subjects
Details
- ISSN :
- 07397240
- Volume :
- 25
- Database :
- OpenAIRE
- Journal :
- Domestic Animal Endocrinology
- Accession number :
- edsair.doi.dedup.....576005afebe78e5dfa75433e02b9d75f