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Effect of cannabinoid receptor agonists on streptozotocin-induced hyperalgesia in diabetic neuropathy
- Source :
- Pharmacology. 82(3)
- Publication Year :
- 2007
-
Abstract
- The effect of CB-1 and CB-2 receptor agonists, as well as an influence of a non-selective inhibitor of nitric oxide synthase (NOS), L-NOArg, and an inhibitor acting preferentially on cyclooxygenase-1 (COX-1), indomethacin, on the action of cannabinoid receptor agonists in a streptozotocin (STZ)-induced neuropathic model was investigated. When administered alone, a non-selective cannabinoid receptor agonist, WIN 55,212-2, a potentially selective CB-1 cannabinoid receptor agonist, Met-F-AEA, and a selective CB-2 cannabinoid receptor agonist, AM1241, dose-dependently reduced STZ-induced hyperalgesia. The results of the present study also demonstrated that inhibitors of COX and NOS increase antihyperalgesic activity of low doses of CB-1 and CB-2 receptor agonists. Hypothetical consequences of this phenomenon are discussed.
- Subjects :
- Male
medicine.medical_specialty
Diabetic neuropathy
Morpholines
Indomethacin
Arachidonic Acids
Naphthalenes
Nitroarginine
Streptozocin
Diabetes Mellitus, Experimental
Receptor, Cannabinoid, CB2
Diabetic Neuropathies
Receptor, Cannabinoid, CB1
Internal medicine
medicine
Animals
Cyclooxygenase Inhibitors
Rats, Wistar
WIN 55,212-2
Receptor
Pharmacology
Analgesics
biology
Dose-Response Relationship, Drug
business.industry
Cannabinoids
Cannabinoid Receptor Agonists
Drug Synergism
General Medicine
medicine.disease
Streptozotocin
Endocannabinoid system
Benzoxazines
Rats
Nitric oxide synthase
Endocrinology
Hyperalgesia
biology.protein
medicine.symptom
Nitric Oxide Synthase
business
medicine.drug
Subjects
Details
- ISSN :
- 14230313
- Volume :
- 82
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Pharmacology
- Accession number :
- edsair.doi.dedup.....575defa536e23a2c846e94e777f25027