Back to Search
Start Over
Enrichment of minor allele of SNPs and genetic prediction of type 2 diabetes risk in British population
- Source :
- PLoS ONE, PLoS ONE, Vol 12, Iss 11, p e0187644 (2017)
- Publication Year :
- 2017
- Publisher :
- Public Library of Science, 2017.
-
Abstract
- Type 2 diabetes (T2D) is a complex disorder characterized by high blood sugar, insulin resistance, and relative lack of insulin. The collective effects of genome wide minor alleles of common SNPs, or the minor allele content (MAC) in an individual, have been linked with quantitative variations of complex traits and diseases. Here we studied MAC in T2D using previously published SNP datasets and found higher MAC in cases relative to matched controls. A set of 357 SNPs was found to have the best predictive accuracy in a British population. A weighted risk score calculated by using this set produced an area under the curve (AUC) score of 0.86, which is comparable to risk models built by phenotypic markers. These results identify a novel genetic risk element in T2D susceptibility and provide a potentially useful genetic method to identify individuals with high risk of T2D.
- Subjects :
- 0301 basic medicine
Heredity
Physiology
Population genetics
lcsh:Medicine
Genome-wide association study
Type 2 diabetes
Biochemistry
Body Mass Index
Habits
0302 clinical medicine
Endocrinology
Mathematical and Statistical Techniques
Medicine and Health Sciences
Smoking Habits
030212 general & internal medicine
lcsh:Science
Genetics
education.field_of_study
Principal Component Analysis
Multidisciplinary
Genomics
Lipids
3. Good health
Type 2 Diabetes
Cholesterol
Physiological Parameters
Physical Sciences
Statistics (Mathematics)
Research Article
Endocrine Disorders
Population
Single-nucleotide polymorphism
Biology
Research and Analysis Methods
03 medical and health sciences
Insulin resistance
medicine
Diabetes Mellitus
Genome-Wide Association Studies
Allele
Statistical Methods
education
Behavior
Complex Traits
lcsh:R
Body Weight
Biology and Life Sciences
Computational Biology
Human Genetics
medicine.disease
Genome Analysis
Minor allele frequency
030104 developmental biology
Metabolic Disorders
Multivariate Analysis
lcsh:Q
Mathematics
Forecasting
Subjects
Details
- Language :
- English
- ISSN :
- 19326203
- Volume :
- 12
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- PLoS ONE
- Accession number :
- edsair.doi.dedup.....57579f58ed36bbd6fe8119ea27f61354