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Mesenchymal Stem Cell: Keystone of the Hematopoietic Stem Cell Niche and a Stepping-Stone for Regenerative Medicine
- Source :
- Annual Review of Immunology, Vol. 31 (2013) pp. 285-316
- Publication Year :
- 2013
- Publisher :
- Annual Reviews, 2013.
-
Abstract
- Mesenchymal stem cells (MSCs) are self-renewing precursor cells that can differentiate into bone, fat, cartilage, and stromal cells of the bone marrow. Recent studies suggest that MSCs themselves are critical for forming a niche that maintains hematopoietic stem cells (HSCs). The ease by which human MSC-like and stromal progenitor cells can be isolated from the bone marrow and other tissues has led to the rapid development of clinical investigations exploring their anti-inflammatory properties, tissue preservation capabilities, and regenerative potential. However, the identity of genuine MSCs and their specific contributions to these various beneficial effects have remained enigmatic. In this article, we examine the definition of MSCs and discuss the importance of rigorously characterizing their stem cell activity. We review their role and that of other putative niche constituents in the regulation of bone marrow HSCs. Additionally, how MSCs and their stromal progeny alter immune function is discussed, as well as potential therapeutic implications.
- Subjects :
- Hematopoietic Stem Cell Transplantation/methods
Regenerative Medicine/methods
Hematopoietic stem cell niche
Immunology
Clinical uses of mesenchymal stem cells
Bone Marrow Cells
Biology
Bone Marrow Cells/immunology/pathology
Mesenchymal Stem Cell Transplantation
Regenerative Medicine
Inflammation/immunology/pathology/therapy
medicine
Animals
Humans
Immunology and Allergy
Progenitor cell
Stem cell transplantation for articular cartilage repair
Inflammation
Stem Cells
Mesenchymal stem cell
Hematopoietic Stem Cell Transplantation
Stem Cells/immunology
Cell biology
medicine.anatomical_structure
Mesenchymal Stem Cell Transplantation/methods
Stromal Cells/immunology/pathology/transplantation
Bone marrow
Stromal Cells
Stem cell
Adult stem cell
Subjects
Details
- ISSN :
- 15453278 and 07320582
- Volume :
- 31
- Database :
- OpenAIRE
- Journal :
- Annual Review of Immunology
- Accession number :
- edsair.doi.dedup.....5740e413dab57dc002f505074c179119