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Impact of the pretreatment Glasgow prognostic score on treatment tolerance, toxicities, and survival in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy
- Source :
- Head & Neck. 39:1990-1996
- Publication Year :
- 2017
- Publisher :
- Wiley, 2017.
-
Abstract
- Background The purpose of this study was to evaluate the impact of the pretreatment Glasgow prognostic score on treatment-related toxicities, tolerance, and survival in patients with advanced head and neck cancers undergoing concurrent chemoradiotherapy (CRT). Methods We retrospectively analyzed and compared the clinical characteristics, toxicities, and survival of 143 patients with stages III, IVA, and IVB head and neck cancer treated with concurrent CRT according to their Glasgow prognostic score between 2007 and 2010. Results The Glasgow prognostic score was correlated with advanced tumor stage and T/N classification. Patients with a higher Glasgow prognostic score were less likely to tolerate concurrent CRT, experienced more weight loss, required tube feeding support more frequently, and had higher percentage of grade ≥3 hematological toxicities, sepsis, and toxic death. Patients with a Glasgow prognostic score of 0 had better overall and recurrence-free survival than those with a Glasgow prognostic score of 1 or 2. Conclusion Pretreatment Glasgow prognostic score predicts treatment tolerance, toxicity, and survival in patients with advanced head and neck cancer undergoing concurrent CRT.
- Subjects :
- Adult
Male
0301 basic medicine
Oncology
medicine.medical_specialty
Prognostic score
Sepsis
03 medical and health sciences
0302 clinical medicine
Weight loss
Internal medicine
Tumor stage
medicine
Humans
In patient
Aged
Neoplasm Staging
Retrospective Studies
Squamous Cell Carcinoma of Head and Neck
business.industry
Head and neck cancer
Chemoradiotherapy
Middle Aged
Prognosis
medicine.disease
Treatment tolerance
Surgery
Concurrent chemoradiotherapy
Survival Rate
Treatment Outcome
030104 developmental biology
Otorhinolaryngology
Head and Neck Neoplasms
030220 oncology & carcinogenesis
Carcinoma, Squamous Cell
Female
medicine.symptom
business
Subjects
Details
- ISSN :
- 10433074
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Head & Neck
- Accession number :
- edsair.doi.dedup.....573cc40a7d5ee45497970748e06db108