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Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1β production
- Source :
- Nature Immunology. 11:63-69
- Publication Year :
- 2009
- Publisher :
- Springer Science and Business Media LLC, 2009.
-
Abstract
- Interleukin 1 beta (IL-1 beta) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by transcription of Il1b dependent on the transcription factor NF-kappaB and subsequent processing of pro-IL-1 beta by an inflammasome. However, the sensors and mechanisms that facilitate RNA virus-induced production of IL-1 beta are not well defined. Here we report a dual role for the RNA helicase RIG-I in RNA virus-induced proinflammatory responses. Whereas RIG-I-mediated activation of NF-kappaB required the signaling adaptor MAVS and a complex of the adaptors CARD9 and Bcl-10, RIG-I also bound to the adaptor ASC to trigger caspase-1-dependent inflammasome activation by a mechanism independent of MAVS, CARD9 and the Nod-like receptor protein NLRP3. Our results identify the CARD9-Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish RIG-I as a sensor able to activate the inflammasome in response to certain RNA viruses.
- Subjects :
- Interferon-Induced Helicase, IFIH1
viruses
Immunoblotting
Interleukin-1beta
Immunology
bcl-X Protein
Enzyme-Linked Immunosorbent Assay
Biology
Models, Biological
Vesicular stomatitis Indiana virus
Cell Line
DEAD-box RNA Helicases
Mice
RNA Virus Infections
Interleukin-1 beta production
Transcription (biology)
medicine
Animals
Humans
RNA Viruses
Immunology and Allergy
Encephalomyocarditis virus
DEAD Box Protein 58
Transcription factor
Cells, Cultured
Adaptor Proteins, Signal Transducing
Inflammation
Mice, Knockout
RIG-I
Caspase 1
RNA
Inflammasome
Virology
RNA Helicase A
Cell biology
CARD Signaling Adaptor Proteins
Enzyme Activation
Host-Pathogen Interactions
Signal Transduction
medicine.drug
Subjects
Details
- ISSN :
- 15292916 and 15292908
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Nature Immunology
- Accession number :
- edsair.doi.dedup.....572e2f8686d95f1909922dce333f6b7e
- Full Text :
- https://doi.org/10.1038/ni.1824