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Long-Term Follow-up and Quantitative Hepatitis B Surface Antigen Monitoring in North American Chronic HBV Carriers
- Source :
- Annals of Hepatology, Vol 17, Iss 2, Pp 232-241 (2018)
- Publication Year :
- 2018
- Publisher :
- Elsevier, 2018.
-
Abstract
- Introduction. Quantitative hepatitis B surface antigen (qHBsAg) combined with HBV DNA may be useful for predicting chronic hepatitis B (CHB) activity and nucleoside analogue (NA) response.Material and methods. In this retrospective cohort study we evaluated qHBsAg levels according to CHB disease phase and among patients on treatment. Random effect logistic regression analysis was used to analyze qHBsAg change with time in the NA-treated cohort.Results. 545 CHB carriers [56% M, median age 48 y (IQR 38-59), 73% Asian] had qHBsAg testing. In the untreated group (44%), 8% were classified as immune tolerant, 10% immune clearance, 40% inactive, and 43% had HBeAg- CHB and the median HBsAg levels were 4.6 (IQR 3.4-4.9), 4.0 (IQR 3.4-4.5), 2.9 (IQR 1.4-3.8), and 3.2 log IU/mL (IQR 2.6-4.0), respectively; p < 0.001. In the NA-treated group (28% entecavir, 68% tenofovir, 4% lamivudine), no significant change in qHBsAg levels occured with time. However, 19% of patients on long-term NA had sustained qHBsAg < 2 log10 IU/mL.Conclusion. qHBsAg titers were associated with CHB phase and remained stable in those on long-term NA. A significant number of treated patients had low-level qHBsAg, of which some may be eligible for treatment discontinuation without risk of flare.
- Subjects :
- Adult
Male
0301 basic medicine
Hepatitis B virus
HBsAg
medicine.medical_specialty
Canada
Time Factors
Specialties of internal medicine
Antiviral Agents
Gastroenterology
03 medical and health sciences
Hepatitis B, Chronic
0302 clinical medicine
Disease Phase
Predictive Value of Tests
Internal medicine
medicine
Humans
Retrospective Studies
Hepatitis B Surface Antigens
Hepatology
Nucleoside analogue
business.industry
Reproducibility of Results
Lamivudine
Retrospective cohort study
General Medicine
Entecavir
Middle Aged
Viral Load
Discontinuation
Treatment Outcome
030104 developmental biology
HBeAg
RC581-951
DNA, Viral
Cohort
Diagnostic Test
Female
030211 gastroenterology & hepatology
Drug Monitoring
Chronic Hepatitis B
business
Nucleoside Analogues
Biomarkers
Follow-Up Studies
medicine.drug
Natural History
Subjects
Details
- Language :
- English
- ISSN :
- 16652681
- Volume :
- 17
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Annals of Hepatology
- Accession number :
- edsair.doi.dedup.....572100b8c90ee7769ef9d71b954bd325