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AMISH EYE STUDY: Baseline Spectral Domain Optical Coherence Tomography Characteristics of Age-Related Macular Degeneration
- Source :
- Retina (Philadelphia, Pa.). 39(8)
- Publication Year :
- 2018
-
Abstract
- PURPOSE: To describe spectral domain optical coherence tomography (SD-OCT) findings in an Amish cohort to assess SD-OCT markers for early age-related macular degeneration (AMD). METHODS: The authors performed a family-based prospective cohort study of 1,146 elderly Amish subjects (age range 50–99 years) (2,292 eyes) who had a family history of at least 1 individual with AMD. All subjects underwent complete ophthalmic examinations, SD-OCT using both Cirrus and Spectralis (20 × 20° scan area) instruments, fundus auto-fluorescence, infrared imaging, and color fundus photography. Spectral domain optical coherence tomography characteristics were analyzed in subjects with AMD (with and without subretinal drusenoid deposits [SDDs]) and normal healthy cohorts. RESULTS: Participants’ mean age was 65.2 years (SD ± 11). Color fundus photographic findings in 596 (53%) subjects (1,009 eyes) were consistent with AMD; the remaining 478 (43%) subjects showed no signs of AMD. The choroid was significantly thinner on OCT (242 ± 76 μm, P < 0.001) in those with AMD compared with those without (263 ± 63 μm). Subretinal drusenoid deposits were found in 143 eyes (7%); 11 of the 143 eyes (8%) had no other manifestations of AMD. Drusen volume (P < 0.001) and area of geographic atrophy (P < 0.001) were significantly greater, and choroid was significantly (P < 0.001) thinner in subjects with SDDs versus those without SDDs. CONCLUSION: The authors describe spectral domain optical coherence tomography characteristics in an elderly Amish population with and without AMD, including the frequency of SDD. Although relatively uncommon in this population, the authors confirmed that SDDs can be found in the absence of other features of AMD and that eyes with SDDs have thinner choroids.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
genetic structures
Population
Retinal Drusen
Drusen
Fundus (eye)
Article
03 medical and health sciences
Macular Degeneration
0302 clinical medicine
Optical coherence tomography
Ophthalmology
medicine
Humans
Prospective Studies
Prospective cohort study
education
Aged
Aged, 80 and over
Observer Variation
education.field_of_study
medicine.diagnostic_test
business.industry
Reproducibility of Results
General Medicine
Macular degeneration
Middle Aged
medicine.disease
eye diseases
030104 developmental biology
medicine.anatomical_structure
Cohort
030221 ophthalmology & optometry
Female
Choroid
sense organs
business
Amish
Biomarkers
Tomography, Optical Coherence
Subjects
Details
- ISSN :
- 15392864
- Volume :
- 39
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Retina (Philadelphia, Pa.)
- Accession number :
- edsair.doi.dedup.....57200d4c6109ea7bdd4e790253011101