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Differentiation and regeneration of adrenal tissues: An initial step toward regeneration therapy for steroid insufficiency
- Source :
- Endocrine journal. 53(4)
- Publication Year :
- 2006
-
Abstract
- In animal experiments, adrenal cortical tissue has been successfully regenerated through xenotransplantation of cloned adrenocortical cells, suggesting that the intraadrenal stem cells required for such tissue formation may be present in the adrenal cortex. Stable expression of Ad4BP/SF-1, a key factor for adrenal and gonadal development and steroidogenesis, has been shown to direct embryonic stem cells toward the steroidogenic lineage. However, this steroidogenic capacity was very limited since progesterone was only produced in the presence of an exogenous substrate. Bone marrow mesenchymal cells are thought to contain pluripotent progenitor cells, which differentiate into multiple lineages. We have demonstrated that adenovirus-mediated forced expression of SF-1 in long-term cultured bone marrow cells can produce steroidogenic cells with the capacity for de novo synthesis of various steroid hormones in response to ACTH. This discovery may represent the first step in autologous cell transplantation therapy for patients with steroid hormone deficiency.
- Subjects :
- Steroidogenic factor 1
Male
medicine.medical_specialty
Cell Transplantation
Endocrinology, Diabetes and Metabolism
medicine.medical_treatment
Receptors, Cytoplasmic and Nuclear
Biology
Steroidogenic Factor 1
Mice
Endocrinology
Internal medicine
medicine
Animals
Humans
Regeneration
Progenitor cell
Homeodomain Proteins
Adrenal cortex
Mesenchymal stem cell
Cell Differentiation
Mesenchymal Stem Cells
Genetic Therapy
Embryonic stem cell
Steroid hormone
medicine.anatomical_structure
Adrenal Cortex
Female
Steroids
Bone marrow
Stem cell
Adrenal Insufficiency
Transcription Factors
Subjects
Details
- ISSN :
- 09188959
- Volume :
- 53
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Endocrine journal
- Accession number :
- edsair.doi.dedup.....571b5365753d986eecf6920e78a240f3