Synthesis and stability studies in physiological-like conditions of a new compound of copper(II) with mixed ligands

University of Bucharest, Faculty of Chemistry, Department of Inorganic Chemistry, 23 Dumbrava Rosie, Bucuresti, Romania E-mail: veronica.pop@k.ro Manuscript received 14 November 2002, accepted 31 January 2003 In order to obtain new potential antioxidants with molecular mass lower than those of the metal-proteins, a new copper(II) compound with mixed ligands, L-histidine and urea was synthesised. The compounds containing only one of the two mentioned ligands, Cu-urea and Cu-L-histidine was also synthesised as intermediates in the synthesis of the compound with mixed ligands or for comparative purposes. The spectral analysis indicates an axial symmetry of the Cull ions in the compound with mixed ligands. Stability studies, in time and in different pH-conditions, were carried out by absorption electronic spectroscopy; the results revealed satisfactory stability in time, at the pH of the physiologic scrum of the compounds with mixed ligands; the compound is also stable in aqueous solutions at pH 7.2-5.5 . The study of compatibility with physiological mediums indicates that the compound displays significant lypophilic character.